Background Acetaminophen (paracetamol, APAP) overdose is the principal cause of acute
liver injury (ALI) that leads to liver failure typified with oxidative stress, mitochondrial and …

Acetaminophen (APAP) overdose is one of the most common causes of drug‐induced acute
liver failure in humans. To investigate the hepatoprotective effect of salvianolic acid C (SAC) …

Abstract Background Tanshinone IIA (Tan), the main active component of Salvia miltiorrhiza,
has been demonstrated to have antioxidant activity. Acetaminophen (APAP), a widely used …

Acetaminophen (APAP) overdose is the main cause of acute liver failure. Apigenin (API) is a
natural dietary flavonol with high antioxidant capacity. Herein, we investigated protection by …

Excess acetaminophen (APAP) commonly causes severe acute liver injury (ALI),
characterized by oxidative stress, pro-inflammatory responses, and hepatocyte damage …

Summary Acetaminophen (N-acetyl-p-aminophenol, APAP) overdose causes hepatotoxicity,
even liver failure, and oxidative stress plays pivotal role in its pathogenesis. Nicotinic acid …

Acetaminophen (APAP)-induced liver injury (AILI) is the main cause of acute liver failure in
the developed countries. The present study aimed to evaluate the therapeutic efficacy of …

Acetaminophen (APAP) overdose causes acute liver injury and leads to fatal liver damage.
However, the therapies are quite limited. Shikonin is a natural product with antioxidant and …

The liver plays a vital role in metabolism, synthesis, and detoxification, but it is susceptible to
damage from various factors such as viral infections, drug reactions, excessive alcohol …

Amygdalin is a natural compound from Bitter Apricot Seed which is reported to have anti-
inflammatory activity. Acetaminophen (APAP) resulted in drug-induced liver injury is the …