Progesterone and allopregnanolone rapidly attenuate estrogen-associated mechanical allodynia in rats with persistent temporomandibular joint inflammation

RS Hornung, WL Benton, S Tongkhuya… - Frontiers in integrative …, 2020 - frontiersin.org
Temporomandibular joint disorder (TMD) is associated with pain in the joint
(temporomandibular joint, TMJ) and muscles involved in mastication. TMD pain dissipates …

Peripheral estradiol induces temporomandibular joint antinociception in rats by activating the nitric oxide/cyclic guanosine monophosphate signaling pathway

NC Favaro-Moreira, KE Torres-Chavez, L Fischer… - Neuroscience, 2009 - Elsevier
Recently, we have reported that high physiological estradiol level during the proestrus
phase of the estrous cycle or systemic estradiol administration in ovariectomized rats …

Modulation of temporomandibular joint nociception and inflammation in male rats after administering a physiological concentration of 17β‐oestradiol

PR Kramer, LL Bellinger - European Journal of Pain, 2013 - Wiley Online Library
Background Previous studies have shown 17β‐estradiol will reduce temporomandibular
joint (TMJ) inflammation and hypersensitivity in female rats. Although male rats contain …

[HTML][HTML] The influence of sex and ovarian hormones on temporomandibular joint nociception in rats

L Fischer, KE Torres-Chávez, JT Clemente-Napimoga… - The Journal of …, 2008 - Elsevier
The aim of this study was to investigate the influence of sex and ovarian hormones on
formalin-and glutamate-induced temporomandibular joint nociception in rats. The influence …

Estrogen and inflammation increase the excitability of rat temporomandibular joint afferent neurons

NM Flake, DB Bonebreak… - Journal of …, 2005 - journals.physiology.org
Several painful conditions, including temporomandibular disorders (TMD), are more
prevalent and more severe in women than in men. Although the physiological basis for this …

17-β-estradiol enhanced allodynia of inflammatory temporomandibular joint through upregulation of hippocampal TRPV1 in ovariectomized rats

YW Wu, YP Bi, XX Kou, W Xu, LQ Ma… - Journal of …, 2010 - Soc Neuroscience
Temporomandibular disorders (TMDs) predominantly affect reproductive female patients,
with pain the most frequent complaint. Although estrogens are believed to play important …

Progesterone attenuates temporomandibular joint inflammation through inhibition of NF-κB pathway in ovariectomized rats

XT Xue, XX Kou, CS Li, RY Bi, Z Meng, XD Wang… - Scientific reports, 2017 - nature.com
Sex hormones may contribute to the symptomatology of female-predominant
temporomandibular disorders (TMDs) inflammatory pain. Pregnant women show less …

17β-Estradiol exacerbated experimental occlusal interference-induced chronic masseter hyperalgesia by increasing the neuronal excitability and TRPV1 function of …

Y Liu, XX Xu, Y Cao, SY Mo, SS Bai, YY Fan… - International Journal of …, 2021 - mdpi.com
Pain symptoms in temporomandibular disorders (TMD) predominantly affect reproductive
women, suggesting that estrogen regulates pain perception. However, how estrogen …

The effects of cycling levels of 17β-estradiol and progesterone on the magnitude of temporomandibular joint-induced nociception

PR Kramer, LL Bellinger - Endocrinology, 2009 - academic.oup.com
A greater incidence of temporomandibular joint (TMJ) pain is reported in females,
suggesting that gonadal hormones may play a role in this condition. However, the exact …

Hormone replacement therapy did not alleviate temporomandibular joint inflammatory pain in ovariectomized rats

GPH Kroeff, JM de Castro, HB Braga, TD Bosco… - Odontology, 2024 - Springer
This study had the aim of examining the relationships between variations in estrogen levels
resulting from ovariectomy, and estrogen hormone replacement therapy (HRT) in rats …