Oxidative damage has been implicated in the pathogenesis of colorectal cancer (CRC). The
base excision repair (BER) pathway is the major DNA repair pathway for oxidative DNA …

Aim of this study was to analyze the correlation between polymorphisms of ERCC2 and
ERCC5 genes and efficiency of repair of oxidative DNA damage with the risk of colorectal …

Humans are continually exposed to a large number of environmental carcinogens [1], some
of them share a specific toxicity model which acts via the enhancement of cellular levels of …

DNA oxidative lesions are widely considered as a potential risk factor for colorectal cancer
development. The aim of this work was to determine the role of the efficiency of base …

Although the developmental stages of gastric carcinoma are still not clear, the constantly
generated reactive oxygen and nitrogen species (ROS/RNS) may contribute to the process …

The contribution of polymorphisms of DNA repair genes OGG1 Ser326Cys, XPC Lys939Gln,
and XPD Lys751Gln in developing colorectal carcinoma is controversial. Whether the group …

Background: Genetic polymorphisms in DNA repair genes may influence individual variation
in DNA repair capacity, which may be associated with risk of developing cancer. For …

We investigated association between polymorphisms in DNA repair genes and the capacity
to repair DNA damage induced by γ-irradiation and by base oxidation in a healthy …

Oxidative stress, oxidative DNA damage and resulting mutations play a role in colorectal
carcinogenesis. Impaired equilibrium between DNA damage formation, antioxidant status …

Oxidatively damaged DNA base lesions are considered to be mainly repaired by 8-
oxoguanine DNA glycosylase (OGG1) mediated pathways. We investigated the effect of the …