In older individuals, pulmonary artery pressure rises markedly during exercise, probably due
in part to increased pulmonary vascular resistance and in part to an increase in left‐heart …

Sustained hypoxia over several hours induces a progressive rise in pulmonary artery
systolic pressure (PASP). Administration of intravenous iron immediately prior to the hypoxia …

Intravenous iron administration is typically indicated in individuals who have iron deficiency
refractory to oral iron. However, in certain chronic disease states such as heart failure, it may …

Hypoxia is a major cause of pulmonary hypertension. Gene expression activated by the
transcription factor hypoxia‐inducible factor (HIF) is central to this process. The oxygen …

Context Hypoxia is a major cause of pulmonary hypertension in respiratory disease and at
high altitude. Recent work has established that the effect of hypoxia on pulmonary arterial …

Iron and oxygen are essential to aerobic organisms, and their biologic functions are
intertwined. For example, iron as a component of hemoglobin is required for oxygen …

In patients with idiopathic pulmonary arterial hypertension (iPAH), iron deficiency is common
and has been associated with reduced exercise capacity and worse survival. Previous …

Rationale: Iron deficiency, in the absence of anemia, is common in patients with idiopathic
and heritable pulmonary arterial hypertension (PAH) and is associated with a worse clinical …

The purpose of this review article is to provide a comprehensive review of iron deficiency in
the setting of pulmonary arterial hypertension (PAH) and to evaluate the utility of iron …

Our aim is to assess the safety and potential clinical benefit of intravenous iron (Ferinject)
infusion in iron deficient patients with idiopathic pulmonary arterial hypertension (IPAH). Iron …