[HTML][HTML] Recent advances in the molecular pathophysiology of atrial fibrillation

R Wakili, N Voigt, S Kääb, D Dobrev… - The Journal of clinical …, 2011 - Am Soc Clin Investig
Atrial fibrillation (AF) is an extremely common cardiac rhythm disorder that causes
substantial morbidity and contributes to mortality. The mechanisms underlying AF are …

Molecular basis of atrial fibrillation pathophysiology and therapy: a translational perspective

S Nattel, J Heijman, L Zhou, D Dobrev - Circulation research, 2020 - Am Heart Assoc
Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

Mechanisms of atrial fibrillation

RS Wijesurendra, B Casadei - Heart, 2019 - heart.bmj.com
Atrial fibrillation (AF) is the most common sustained arrhythmia, currently affecting over 33
million individuals worldwide, and its prevalence is expected to more than double over the …

Mechanisms and drug development in atrial fibrillation

D Calvo, D Filgueiras-Rama, J Jalife - Pharmacological Reviews, 2018 - ASPET
Atrial fibrillation is a highly prevalent cardiac arrhythmia and the most important cause of
embolic stroke. Although genetic studies have identified an increasing assembly of AF …

The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis

J Heijman, V Algalarrondo, N Voigt… - Cardiovascular …, 2016 - academic.oup.com
Atrial fibrillation (AF) is an extremely common clinical problem associated with increased
morbidity and mortality. Current antiarrhythmic options include pharmacological, ablation …

Genetic mechanisms of atrial fibrillation: impact on response to treatment

D Darbar, DM Roden - Nature Reviews Cardiology, 2013 - nature.com
Atrial fibrillation (AF) is the most-common sustained arrhythmia observed in clinical practice,
but response to therapy is highly variable between patients. Current drug therapies to …

Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation

S Nattel, D Dobrev - Nature Reviews Cardiology, 2016 - nature.com
Atrial fibrillation (AF) is an extremely prevalent arrhythmia that presents a wide range of
therapeutic challenges. AF usually begins in a self-terminating paroxysmal form (pAF). With …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Basic mechanisms of atrial fibrillation—very new insights into very old ideas

S Nattel, D Li, L Yue - Annual Review of Physiology, 2000 - annualreviews.org
▪ Abstract Atrial fibrillation (AF) was recognized and studied extensively in the early twentieth
century, but many fundamental aspects of the arrhythmia were poorly understood until quite …

Therapeutic implications of atrial fibrillation mechanisms: can mechanistic insights be used to improve AF management?

S Nattel - Cardiovascular research, 2002 - academic.oup.com
Atrial fibrillation (AF) is a very common clinical problem, and presently available treatment
options are suboptimal. A tremendous amount has been learned over the past 10 years …