Immunogenic cell death-relevant damage-associated molecular patterns and sensing receptors in triple-negative breast cancer molecular subtypes and implications …

M Xu, J Lu, Y Zhong, J Jiang, Y Shen, J Su… - Frontiers in oncology, 2022 - frontiersin.org
Objectives Triple-negative breast cancer (TNBC) is defined as a highly aggressive type of
breast cancer which lacks specific biomarkers and drug targets. Damage-associated …

Identification of immunosuppressive signature subtypes and prognostic risk signatures in triple-negative breast cancer

R Ding, Y Wang, J Fan, Z Tian, S Wang, X Qin… - Frontiers in …, 2023 - frontiersin.org
Purpose Immune checkpoint blockade (ICB) therapy has transformed the treatment of triple-
negative breast cancer (TNBC) in recent years. However, some TNBC patients with high …

Transcriptome-based network analysis unveils eight immune-related genes as molecular signatures in the immunomodulatory subtype of triple-negative breast cancer

J Zhang, L Wang, X Xu, X Li, W Guan, T Meng… - Frontiers in …, 2020 - frontiersin.org
Objective: Triple-negative breast cancer (TNBC) is a high heterogeneity cancer. The
identification of genomic aberrations that drive each of the TNBC subtypes may predict the …

[HTML][HTML] MYC suppresses STING-dependent innate immunity by transcriptionally upregulating DNMT1 in triple-negative breast cancer

SY Wu, Y Xiao, JL Wei, XE Xu, X Jin, X Hu… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast
cancer and lacks definite treatment targets. Tumor immune microenvironment (TIME) …

Age-related mutational signature negatively associated with immune activity and survival outcome in triple-negative breast cancer

H Chen, W Chong, X Yang, Y Zhang, S Sang… - …, 2020 - Taylor & Francis
Triple-negative breast cancer (TNBC) is characterized by broad genomic and transcriptional
heterogeneity and results in a worse prognosis than other breast cancer types. Here, we …

[HTML][HTML] An immune-related gene prognostic index for triple-negative breast cancer integrates multiple aspects of tumor-immune microenvironment

X Wang, W Su, D Tang, J Jing, J Xiong, Y Deng, H Liu… - Cancers, 2021 - mdpi.com
Simple Summary Triple-negative breast cancer (TNBC) is the most refractory subtype of
breast cancer. Immune checkpoint inhibitor (ICI) therapy has made progress in TNBC …

Immune classification and immune landscape analysis of triple-negative breast cancer

S Hu, X Qu, Y Jiao, J Hu, B Wang - Frontiers in Genetics, 2021 - frontiersin.org
Background: To classify triple-negative breast cancer (TNBC) immunotyping using the public
database, analyze the differences between subtypes in terms of clinical characteristics and …

[HTML][HTML] A comprehensive immunologic portrait of triple-negative breast cancer

Z Liu, M Li, Z Jiang, X Wang - Translational oncology, 2018 - Elsevier
Triple-negative breast cancer (TNBC) is a high-risk malignancy due to its high capacity for
invasion and lack of targeted therapy. Immunotherapy continues to demonstrate efficacy in a …

Decoding immune heterogeneity of triple negative breast cancer and its association with systemic inflammation

S Romero-Cordoba, E Meneghini, M Sant, MV Iorio… - Cancers, 2019 - mdpi.com
Triple negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic
options. New opportunities are emerging from current comprehensive characterization of …

Immune-related biomarkers in triple-negative breast cancer

J Zhang, Q Tian, M Zhang, H Wang, L Wu, J Yang - Breast Cancer, 2021 - Springer
Breast cancer is a commonly diagnosed female cancer in the world. Triple-negative breast
cancer (TNBC) is the most dangerous and biologically aggressive subtype in breast cancer …