Novel applications of trophic factors, Wnt and WISP for neuronal repair and regeneration in metabolic disease

K Maiese - Neural regeneration research, 2015 - journals.lww.com
Diabetes mellitus affects almost 350 million individuals throughout the globe resulting in
significant morbidity and mortality. Of further concern is the growing population of individuals …

Cornerstone Cellular pathways for metabolic disorders and Diabetes Mellitus: non-coding RNAs, wnt signaling, and AMPK

K Maiese - Cells, 2023 - mdpi.com
Metabolic disorders and diabetes (DM) impact more than five hundred million individuals
throughout the world and are insidious in onset, chronic in nature, and yield significant …

Triple play: Promoting neurovascular longevity with nicotinamide, WNT, and erythropoietin in diabetes mellitus

K Maiese - Biomedicine & pharmacotherapy, 2008 - Elsevier
Oxidative stress is a principal pathway for the dysfunction and ultimate destruction of cells in
the neuronal and vascular systems for several disease entities, not promoting the ravages of …

On the common journey of neural cells through ischemic brain injury and Alzheimer's disease

J Kriska, Z Hermanova, T Knotek, J Tureckova… - International Journal of …, 2021 - mdpi.com
Ischemic brain injury and Alzheimer's disease (AD) both lead to cell death in the central
nervous system (CNS) and thus negatively affect particularly the elderly population. Due to …

Wnt signaling in neuroprotection and stem cell differentiation

EM Toledo, M Colombres, NC Inestrosa - Progress in neurobiology, 2008 - Elsevier
In the past several years, we postulated that the loss of Wnt signaling was implicated in the
pathology of Alzheimer's disease (AD). Since then, our lab and other groups have confirmed …

Programming apoptosis and autophagy with novel approaches for diabetes mellitus

K Maiese - Current Neurovascular Research, 2015 - ingentaconnect.com
According to the World Health Organization, diabetes mellitus (DM) in the year 2030 will be
ranked the seventh leading cause of death in the world. DM impacts all systems of the body …

Prospects and perspectives for WISP1 (CCN4) in Diabetes Mellitus

K Maiese - Current neurovascular research, 2020 - ingentaconnect.com
The prevalence of diabetes mellitus (DM) continues to increase throughout the world. In the
United States (US) alone, approximately ten percent of the population is diagnosed with DM …

Diabetes mellitus: channeling care through cellular discovery

K Maiese, YC Shang, ZZ Chong… - Current Neurovascular …, 2010 - ingentaconnect.com
Diabetes mellitus (DM) impacts a significant portion of the world's population and care for
this disorder places an economic burden on the gross domestic product for any particular …

Wnt‐induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease

P Cisternas, JM Zolezzi, M Martinez… - Journal of …, 2019 - Wiley Online Library
Dysregulated Wnt signaling is linked to major neurodegenerative diseases, including
Alzheimer disease (AD). In mouse models of AD, activation of the canonical Wnt signaling …

Glial cell alterations in diabetes-induced neurodegeneration

M Llorián-Salvador, S Cabeza-Fernández… - Cellular and Molecular …, 2024 - Springer
Type 2 diabetes mellitus is a global epidemic that due to its increasing prevalence
worldwide will likely become the most common debilitating health condition. Even if diabetes …