In our early screening process, songorine isolated from Aconitum brachypodum diels
possessed prominent activity of inhibiting class BG protein-coupled receptors (GPCRs). For …

Songorine isolated from Aconitum brachypodum Diels possesses prominent activity of
inhibiting G protein-coupled receptors (GPCRs) in the early screening process. In this paper …

Abstract A series of daphnetin (7, 8-dihydroxycoumarin) derivatives 1–22 were synthesized
including sixteen new compounds (1–5, 7–14, 18, 21 and 22) and six known compounds (6 …

Subtype selectivity and functional bias are vital in current drug discovery for G protein-
coupled receptors (GPCRs) as selective and biased ligands are expected to yield drug …

The orphan G protein-coupled receptor GPR55 has been proposed as a new potential drug
target for the treatment of diabetes, Parkinson's disease, neuropathic pain, and cancer …

Alkaloids are well-studied secondary metabolites, with recent preclinical studies evidencing
that many of them exhibit anti-cancer, anti-depressant, anti-nociceptive, anti-inflammatory …

GPR35, an orphan G protein-coupled receptor, has attracted much attention as a novel
therapeutic target for the treatment of diabetes, hypertension, etc. Recently, 8-substituted …

A series of coumarin-like diacid derivatives were designed and synthesized as novel
agonists of human G-protein-coupled receptor 35 (hGPR35). Active compounds were …

The orphan G-protein-coupled receptor GPR55, which is activated by 1-
lysophosphatidylinositol and interacts with cannabinoid (CB) receptor ligands, has been …

GPR18 and GPR55 are orphan G protein-coupled receptors (GPCRs) that interact with
certain cannabinoid (CB) receptor ligands. In the present study bicyclic imidazole-4-one …