Different neuronal activity patterns induce different gene expression programs
KM Tyssowski, NR DeStefino, JH Cho, CJ Dunn… - Neuron, 2018 - cell.com
A vast number of different neuronal activity patterns could each induce a different set of
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …
activity-regulated genes. Mapping this coupling between activity pattern and gene induction …
Activity-regulated genes as mediators of neural circuit plasticity
JH Leslie, E Nedivi - Progress in neurobiology, 2011 - Elsevier
Modifications of neuronal circuits allow the brain to adapt and change with experience. This
plasticity manifests during development and throughout life, and can be remarkably long …
plasticity manifests during development and throughout life, and can be remarkably long …
An intrinsic transcriptional program underlying synaptic scaling during activity suppression
Homeostatic scaling allows neurons to maintain stable activity patterns by globally altering
their synaptic strength in response to changing activity levels. Suppression of activity by the …
their synaptic strength in response to changing activity levels. Suppression of activity by the …
Mechanisms of specificity in neuronal activity-regulated gene transcription
MR Lyons, AE West - Progress in neurobiology, 2011 - Elsevier
The brain is a highly adaptable organ that is capable of converting sensory information into
changes in neuronal function. This plasticity allows behavior to be accommodated to the …
changes in neuronal function. This plasticity allows behavior to be accommodated to the …
Genome-wide transcriptional changes associated with enhanced activity in the Drosophila nervous system
Z Guan, S Saraswati, B Adolfsen, JT Littleton - Neuron, 2005 - cell.com
Neuronal plasticity is an important feature of the developing brain and requires neuronal
circuits to reconfigure their functional connectivity depending upon activity patterns. To …
circuits to reconfigure their functional connectivity depending upon activity patterns. To …
[引用][C] Transsynaptic control of gene expression
RC Armstrong, MR Montminy - Annual review of neuroscience, 1993 - annualreviews.org
Poised for relay or storage of synaptic information, the postsynaptic neuron must assimilate
a variety of incoming synaptic signals and then integrate these into short-and long-term …
a variety of incoming synaptic signals and then integrate these into short-and long-term …
Shaping synaptic plasticity: the role of activity-mediated epigenetic regulation on gene transcription
J Cortés-Mendoza, SD de León-Guerrero… - International journal of …, 2013 - Elsevier
Learning and memory are basic functions of the brain that allowed human evolution. It is
well accepted that during learning and memory formation the dynamic establishment of new …
well accepted that during learning and memory formation the dynamic establishment of new …
Genetic strategies to access activated neurons
Highlights•IEG promoters driving reporters allow targeting of recently active neurons in
vivo.•Fos-tTA mice drive effectors in previously active neurons for several days.•IEG …
vivo.•Fos-tTA mice drive effectors in previously active neurons for several days.•IEG …
Signaling mechanisms linking neuronal activity to gene expression and plasticity of the nervous system
SW Flavell, ME Greenberg - Annu. Rev. Neurosci., 2008 - annualreviews.org
Sensory experience and the resulting synaptic activity within the brain are critical for the
proper development of neural circuits. Experience-driven synaptic activity causes membrane …
proper development of neural circuits. Experience-driven synaptic activity causes membrane …
The neuronal activity-driven transcriptome
E Benito, A Barco - Molecular Neurobiology, 2015 - Springer
Activity-driven transcription is a key event associated with long-lasting forms of neuronal
plasticity. Despite the efforts to investigate the regulatory mechanisms that control this …
plasticity. Despite the efforts to investigate the regulatory mechanisms that control this …