Introduction: The worldwide population is aging, and several age-associated physiological
and pathophysiological changes can affect drug disposition. This is particularly important in …

Introduction Age-associated physiological changes can alter the disposition of drugs,
however, pathophysiological changes associated with geriatric syndromes in older adults …

This review examines altered drug responses during aging. The incidence of diseases and
disorders that require drug treatment rapidly increases with advancing age; elderly patients …

The biological determinants of drug disposition have been clearly identified and methods
are available to quantify what effects altering them will have on drug kinetics. The factors …

The population of older adults in the United States continues to expand, and the percentage
of patients with multiple comorbid disease states and complex drug regimens has increased …

Ageing is associated with several changes in human organs, which result in altered
medication pharmacokinetics and pharmacodynamics. Ageing is also associated with …

Aging is characterized by a progressive loss of functional capacities of most if not all organs,
a reduction in homeostatic mechanisms, and a response to receptor stimulation. Also, loss of …

BACKGROUND:: Physiologic changes and disease-related alterations in organ function
occur with aging. These changes can affect drug pharmacokinetics in older persons …

Introduction The proportion of the elderly is constantly increasing and by the year 2025 20%
of the population will be above 65 years of age. With advanced age, subjects will develop …

Optimal pharmacotherapy in the elderly is an issue of growing concern especially as the
aged make up an increasing proportion of the population. Central to this issue are two …