Systematic characterization of Ustilago maydis sirtuins shows Sir2 as a modulator of pathogenic gene expression

B Navarrete, JI Ibeas, RR Barrales - Frontiers in Microbiology, 2023 - frontiersin.org
Phytopathogenic fungi must adapt to the different environmental conditions found during
infection and avoid the immune response of the plant. For these adaptations, fungi must …

Sirtuins in epigenetic silencing and control of gene expression in model and pathogenic fungi

G Zhao, LN Rusche - Annual Review of Microbiology, 2022 - annualreviews.org
Fungi, including yeasts, molds, and mushrooms, proliferate on decaying matter and then
adopt quiescent forms once nutrients are depleted. This review explores how fungi use …

Deacetylation by sirtuins is important for Aspergillus fumigatus pathogenesis and virulence

NS Wassano, GB da Silva, AH Reis, JA Gerhardt… - bioRxiv, 2023 - biorxiv.org
Protein acetylation is a crucial post-translational modification that controls gene expression
and a variety of biological processes. Sirtuins, a prominent class of NAD+-dependent lysine …

Sirtuin E is a fungal global transcriptional regulator that determines the transition from the primary growth to the stationary phase

E Itoh, R Odakura, KI Oinuma, M Shimizu… - Journal of Biological …, 2017 - ASBMB
In response to limited nutrients, fungal cells exit the primary growth phase, enter the
stationary phase, and cease proliferation. Although fundamental to microbial physiology in …

Sirtuin E deacetylase is required for full virulence of Aspergillus fumigatus

NS Wassano, GB da Silva, AH Reis… - Communications …, 2024 - nature.com
Aspergillus fumigatus represents a public health problem due to the high mortality rate in
immunosuppressed patients and the emergence of antifungal-resistant isolates. Protein …

Fungus-specific sirtuin HstD coordinates secondary metabolism and development through control of LaeA

M Kawauchi, M Nishiura, K Iwashita - Eukaryotic cell, 2013 - Am Soc Microbiol
The sirtuins are members of the NAD+-dependent histone deacetylase family that contribute
to various cellular functions that affect aging, disease, and cancer development in …

Identifying Genes Devoted to the Cell Death Process in the Gene Regulatory Network of Ustilago maydis

CV Soberanes-Gutiérrez, E Pérez-Rueda… - Frontiers in …, 2021 - frontiersin.org
Cell death is a process that can be divided into three morphological patterns: apoptosis,
autophagy and necrosis. In fungi, cell death is induced in response to intracellular and …

Transcriptomic analysis of the GCN5 gene reveals mechanisms of the epigenetic regulation of virulence and morphogenesis in Ustilago maydis

D Martinez-Soto, JM Gonzalez-Prieto… - FEMS Yeast …, 2015 - academic.oup.com
Chromatin in the eukaryotic nucleus is highly organized in the form of nucleosomes where
histones wrap DNA. This structure may be altered by some chemical modifications of …

The Hos2 Histone Deacetylase Controls Ustilago maydis Virulence through Direct Regulation of Mating-Type Genes

A Elías-Villalobos, A Fernández-Álvarez… - PLoS …, 2015 - journals.plos.org
Morphological changes are critical for host colonisation in plant pathogenic fungi. These
changes occur at specific stages of their pathogenic cycle in response to environmental …

The Deacetylase Sir2 from the Yeast Clavispora lusitaniae Lacks the Evolutionarily Conserved Capacity to Generate Subtelomeric Heterochromatin

CA Froyd, S Kapoor, F Dietrich, LN Rusche - PLoS Genetics, 2013 - journals.plos.org
Deacetylases of the Sir2 or sirtuin family are thought to regulate life cycle progression and
life span in response to nutrient availability. This family has undergone successive rounds of …