Background: Dementia is characterized by a cognitive decline in memory and other domains
that lead to functional impairments. As people age, subjective memory complaints (SMC) …

Background Mild Cognitive Impairment (MCI) is a transitional stage from normal aging to
dementia, characterized by noticeable changes in cognitive function that do not significantly …

Objective Our study aimed to explore the differences in brain microstructure in patients with
Alzheimer's disease (AD) and with mild cognitive impairment (MCI) and in individuals with …

Age-associated white matter degeneration has been well documented and is likely an
important mechanism contributing to cognitive decline in older adults. Recent work has …

The purpose of this explorative study was to investigate whether diffusion tensor imaging
(DTI) and diffusion kurtosis imaging (DKI) parameter changes are reliable measures of white …

This prospective study aimed to explore the white matter microstructural alterations in
Alzheimer's disease (AD) and amnestic mild cognitive impairment (aMCI) using the Tract …

OBJECT: Diffusional kurtosis imaging (DKI), a natural extension of diffusion tensor imaging
(DTI), can characterize non-Gaussian diffusion in the brain. We investigated the capability of …

Objective The Alzheimer's continuum is biologically defined by beta‐amyloid deposition,
which at the earliest stages is superimposed upon white matter degeneration in aging …

Structural and diffusion kurtosis imaging (DKI) can be used to assess hippocampal
macrostructural and microstructural alterations respectively, in Alzheimer's disease (AD) …

Background Age-related changes in brain white matter have been associated with cognitive
decline and Alzheimer's disease. Here, with advanced biophysical modeling of Diffusional …