Untapped potential of multicenter studies: a review of cardiovascular risk prediction models revealed inappropriate analyses and wide variation in reporting

L Wynants, DM Kent, D Timmerman… - … and prognostic research, 2019 - Springer
Background Clinical prediction models are often constructed using multicenter databases.
Such a data structure poses additional challenges for statistical analysis (clustered data) but …

Comparisons of established risk prediction models for cardiovascular disease: systematic review

Objective To evaluate the evidence on comparisons of established cardiovascular risk
prediction models and to collect comparative information on their relative prognostic …

Does ignoring clustering in multicenter data influence the performance of prediction models? A simulation study

L Wynants, Y Vergouwe, S Van Huffel… - … methods in medical …, 2018 - journals.sagepub.com
Clinical risk prediction models are increasingly being developed and validated on
multicenter datasets. In this article, we present a comprehensive framework for the …

The roles of predictors in cardiovascular risk models-a question of modeling culture?

C Wallisch, A Agibetov, D Dunkler, M Haller… - BMC Medical Research …, 2021 - Springer
Background While machine learning (ML) algorithms may predict cardiovascular outcomes
more accurately than statistical models, their result is usually not representable by a …

External validation of two Framingham cardiovascular risk equations and the pooled cohort equations: a nationwide registry analysis

C Wallisch, G Heinze, C Rinner, G Mundigler… - International journal of …, 2019 - Elsevier
Background Cardiovascular prevention guidelines advocate the use of statistical risk
equations to predict individual cardiovascular risk. However, predictive accuracy and clinical …

Prediction models for cardiovascular disease risk in the general population: systematic review

JAAG Damen, L Hooft, E Schuit, TPA Debray… - bmj, 2016 - bmj.com
Objective To provide an overview of prediction models for risk of cardiovascular disease
(CVD) in the general population. Design Systematic review. Data sources Medline and …

Impact of sample size on the stability of risk scores from clinical prediction models: a case study in cardiovascular disease

A Pate, R Emsley, M Sperrin, GP Martin… - … and prognostic research, 2020 - Springer
Background Stability of risk estimates from prediction models may be highly dependent on
the sample size of the dataset available for model derivation. In this paper, we evaluate the …

Modelling of longitudinal data to predict cardiovascular disease risk: a methodological review

D Stevens, DA Lane, SL Harrison, GYH Lip… - BMC medical research …, 2021 - Springer
Objective The identification of methodology for modelling cardiovascular disease (CVD) risk
using longitudinal data and risk factor trajectories. Methods We screened MEDLINE-Ovid …

Validation of two Framingham cardiovascular risk prediction algorithms in an Australian population: the 'old'versus the 'new'Framingham equation

E Zomer, A Owen, DJ Magliano… - European Journal of …, 2011 - academic.oup.com
Background Multivariable risk prediction equations attempt to quantify an individual's
cardiovascular risk. Those borne from the Framingham Heart Study remain the most well …

Laboratory-based versus non-laboratory-based World Health Organization risk equations for assessment of cardiovascular disease risk

A Dehghan, A Rayatinejad, R Khezri, D Aune… - BMC Medical Research …, 2023 - Springer
Background The WHO model has laboratory-based and non-laboratory-based versions for
10-year risk prediction of cardiovascular diseases. Due to the fact that in some settings …