P2Y2 receptor agonists, like UTP and ATP, stimulate mucin secretion from goblet cells in
vitro. Therefore, mucin stimulants could be good candidates for the treatment of dry eye …

purpose. Because purinoceptor P2Y 2 receptor agonists elicit increases in net Cl, fluid
transport, and glycoprotein release onto the ocular surface, they are candidates for treatment …

The purpose of this study was to evaluate the ocular safety and tolerability of the P2Y2
receptor agonist, INS365, when applied as eye drops in normal human subjects. This study …

Purpose. The purinergic P2Y 2 receptor agonists stimulate active Cl-transport across the
excised rabbit conjunctival tissue in vitro. We determined whether UTP or ATP could …

Mucins, which play important roles on the ocular surface in wettability, lubrication, and
barrier function, are classified into two categories: secreted mucins and membrane …

Purpose: To investigate the short-term effects of 2 new secretagogue eye drops for dry eye,
3% diquafosol tetrasodium ophthalmic solution (diquafosol) and 2% rebamipide ophthalmic …

The mucin secretagogue 15 (S)-HETE was found to stimulate glycoprotein secretion in
human ocular tissue at submicromolar concentrations in the present studies. Therefore, the …

Purpose: Dry eye is a multifactorial disease of tears and the ocular surface due to tear
deficiency or excessive tear evaporation. Tear film instability is due to a disturbance in …

The tear film, which includes mucins that adhere to foreign particles, rapidly clears allergens
and pathogens from the ocular surface, protecting the underlying tissues. However, the tear …

Purpose: To determine if the gastroprotective drug OPC-12759 increased proliferation of rat
conjunctival goblet cells in culture. Methods: Cultured goblet cells were incubated with 10 …