Interleukin‐1 blockade inhibits the acute inflammatory response in patients with ST‐segment–elevation myocardial infarction
Background ST‐segment–elevation myocardial infarction is associated with an intense
acute inflammatory response and risk of heart failure. We tested whether interleukin‐1 …
acute inflammatory response and risk of heart failure. We tested whether interleukin‐1 …
Interleukin-1 blockade with anakinra and heart failure following ST-segment elevation myocardial infarction: results from a pooled analysis of the VCUART clinical …
Aims ST-segment elevation myocardial infarction (STEMI) is associated with an intense
acute inflammatory response and an increased risk of death and heart failure (HF). In this …
acute inflammatory response and an increased risk of death and heart failure (HF). In this …
Comparative safety of interleukin-1 blockade with anakinra in patients with ST-segment elevation acute myocardial infarction (from the VCU-ART and VCU-ART2 pilot …
A Abbate, MC Kontos, NA Abouzaki… - The American journal of …, 2015 - Elsevier
Two pilot studies of interleukin-1 (IL-1) blockade in ST-segment elevation myocardial
infarction (STEMI) showed blunted acute inflammatory response and overall favorable …
infarction (STEMI) showed blunted acute inflammatory response and overall favorable …
Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth …
A first pilot study of interleukin-1 blockade in ST-segment elevation acute myocardial
infarction showed improved remodeling. In the present second pilot study, we enrolled 30 …
infarction showed improved remodeling. In the present second pilot study, we enrolled 30 …
The effect of interleukin-1 receptor antagonist therapy on markers of inflammation in non-ST elevation acute coronary syndromes: the MRC-ILA Heart Study
AC Morton, AMK Rothman, JP Greenwood… - European heart …, 2015 - academic.oup.com
Abstract Aims Acute coronary syndromes (ACSs) are driven by inflammation within coronary
plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel …
plaque. Interleukin-1 (IL-1) has an established role in atherogenesis and the vessel …
Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra …
A Abbate, MC Kontos, JD Grizzard… - The American journal of …, 2010 - Elsevier
Acute myocardial infarction (AMI) initiates an intense inflammatory response in which
interleukin-1 (IL-1) plays a central role. The IL-1 receptor antagonist is a naturally occurring …
interleukin-1 (IL-1) plays a central role. The IL-1 receptor antagonist is a naturally occurring …
Investigation of the effect of Interleukin-1 receptor antagonist (IL-1ra) on markers of inflammation in non-ST elevation acute coronary syndromes (The MRC-ILA …
DC Crossman, AC Morton, JP Gunn, JP Greenwood… - Trials, 2008 - Springer
Abstract Background Acute Coronary Syndromes account for 15% of deaths in the UK, and
patients remain at significant risk of re-admission for future complications and death …
patients remain at significant risk of re-admission for future complications and death …
Interleukin-1 blockade in acute decompensated heart failure: a randomized, double-blinded, placebo-controlled pilot study
BW Van Tassell, NA Abouzaki, CO Erdle… - Journal of …, 2016 - journals.lww.com
Background: Heart failure is an inflammatory disease. Patients with acute decompensated
heart failure (ADHF) exhibit significant inflammatory activity on admission. We hypothesized …
heart failure (ADHF) exhibit significant inflammatory activity on admission. We hypothesized …
Inflammatory markers and cardiac function in acute coronary syndrome: difference in ST-segment elevation myocardial infarction (STEMI) and in non-STEMI models
PURPOSE: No studies have been addressed to the differences in inflammation kinetics
between ST-segment elevation myocardial infarction (STEMI) and non-ST-segment …
between ST-segment elevation myocardial infarction (STEMI) and non-ST-segment …
Association of IL-8 with infarct size and clinical outcomes in patients with STEMI
C Shetelig, S Limalanathan, P Hoffmann… - Journal of the American …, 2018 - jacc.org
Background: Little is known about the role of interleukin (IL)-8 in patients with acute ST-
segment elevation myocardial infarction (STEMI). Objectives: The aims of this study were to …
segment elevation myocardial infarction (STEMI). Objectives: The aims of this study were to …