Background Cytotoxic effects of radiation play an important role in the treatment of head and
neck cancer. However, irradiation is known to lead to the migration of various cancer cells …

Background Epithelial mesenchymal transition (EMT) participates in the radioresistance of
cancer cells. In this study, we evaluated whether interleukin‐6 (IL‐6) regulates EMT and …

Background Recently it has been shown that radiation induces migration of glioma cells and
facilitates a further spread of tumor cells locally and systemically. The aim of this study was …

Radiotherapy is effective in reducing primary tumors, however, it may enhance macrophage
infiltration to tumor sites, accelerating tumor progression in several ways. We investigated …

Cancer cells have a variety of interactions with neighboring connective tissue, and this
activity primarily involves fibroblasts. Co-culture of fibroblasts derived from human skin with …

PURPOSE: To investigate the mechanism of interleukin-6 (IL-6) activity induced by ionizing
radiation. METHODS AND MATERIALS: Human umbilical vascular endothelial cells …

The tumor stroma performs an important role in carcinogenesis. It predominantly consists of
fibroblasts and the connective tissue produced by them, and undergoes a multitude of …

Radiotherapy (RT) is one of the main treatments for head and neck squamous cell
carcinomas (HNSCCs). Unfortunately, radioresistance is observed in many cases of …

Total resection of adamantinomatous craniopharyngioma (ACP) is complex and often leads
to postoperative recurrence. This is due to the tendency of the tumor to invade the …

Abstract Interleukin-6 (IL-6) is a multifunctional regulator of immune response and
hematopoiesis. Recently, it has been reported that expression of IL-6 is correlated with …