Enzyme-Responsive COF-based thiol-targeting nanoinhibitor for curing bacterial infections

X Wang, B Sun, Z Ye, W Zhang, W Xu… - … Applied Materials & …, 2022 - ACS Publications
Pathogen infections impose severe challenges in clinical practice, especially for patients
infected with antibiotic-resistant microbes. The thioredoxin (Trx) system in Gram-positive …

Metal–Organic Framework‐Derived Homologous Sulfide Heterojunction for Robust Enzyme‐Like Self‐Driven Bacteria‐Killing through Enhanced Electron Transfer

H Wei, Y Luo, C Wang, S Wu, Y Zheng, Y Zhang… - Small …, 2023 - Wiley Online Library
Infectious diseases caused by various bacteria pose a serious threat to human health, and
the emergence of drug‐resistant bacteria has forced humans to develop new and effective …

Hollow cobalt sulfide nanospheres with highly enzyme-like antibacterial activities to accelerate infected wound healing

R Wu, Z Liu, Y Huang, L Huang, J Wang… - Bioconjugate …, 2023 - ACS Publications
The emergence of nanozymes presents a promising alternative to antibiotics for reactive
oxygen species-mediated broad-spectrum antimicrobial purposes, but nanozymes still face …

[HTML][HTML] Gold (I) selenium N-heterocyclic carbene complexes as potent antibacterial agents against multidrug-resistant gram-negative bacteria via inhibiting …

X Chen, S Sun, S Huang, H Yang, Q Ye, L Lv, Y Liang… - Redox Biology, 2023 - Elsevier
Abstract Multidrug-resistant (MDR) Gram-negative bacteria have become a global threat to
human life and health, and novel antibiotics are urgently needed. The thioredoxin (Trx) …

Sprayable CeCuOx Nanocatalytic Gel for Synergistic Antibacterial Therapy

M Xie, Z Wei, Z Niu, H Xu, Y Guo, J Huang… - ACS Applied Nano …, 2023 - ACS Publications
The bacterial microenvironment-activated nanocatalytic antibacterial strategy has attracted
extensive attention owing to the high specificity to eliminate pathogens, which provides …

Designing Single‐Atom Active Sites on sp2‐Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis‐Like for Robust Anti‐Infection Therapy

B Sun, X Wang, Z Ye, J Zhang, X Chen… - Advanced …, 2023 - Wiley Online Library
With the threat posed by drug‐resistant pathogenic bacteria, developing non‐antibiotic
strategies for eradicating clinically prevalent superbugs remains challenging. Ferroptosis is …

Polymetallic Hybrid Nanoplatform with Hyperthermia‐Amplified Dual Enzyme‐Like Activities for Efficient Speeded‐Up Bacterially Infected Wound Healing

X He, Z Deng, JT Hou, X Sun, D Jiang… - Advanced Materials …, 2022 - Wiley Online Library
Antibiotic‐independent artificial nanozymes exhibit excellent biocatalytic activity, and can
generate sufficient reactive oxygen species (ROS) for potential applications in the field of …

Biomimetic metal–organic framework composite-mediated cascade catalysis for synergistic bacteria killing

X Cheng, S Zhang, H Liu, H Chen, J Zhou… - … applied materials & …, 2020 - ACS Publications
Encapsulating nanoparticles/biomolecules into metal–organic freamworks (MOFs) has
proven to be highly effective in creating new functions during their applications. However, it …

Novel gold (III)-dithiocarbamate complex targeting bacterial thioredoxin reductase: Antimicrobial activity, synergy, toxicity, and mechanistic insights

C Ratia, V Ballén, Y Gabasa, RG Soengas… - Frontiers in …, 2023 - frontiersin.org
Introduction Antimicrobial resistance is a pressing global concern that has led to the search
for new antibacterial agents with novel targets or non-traditional approaches. Recently …

An optimally designed engineering exosome–reductive COF integrated nanoagent for synergistically enhanced diabetic fester wound healing

B Sun, F Wu, X Wang, Q Song, Z Ye… - Small, 2022 - Wiley Online Library
Oxidative stress and local overactive inflammation have been considered major obstacles in
diabetic wound treatment. Although antiphlogistic tactics have been reported widely, they …