Dimethyl fumarate, a two‐edged drug: current status and future directions

NEB Saidu, N Kavian, K Leroy, C Jacob… - Medicinal research …, 2019 - Wiley Online Library
Dimethyl fumarate (DMF) is a fumaric acid ester registered for the treatment of relapsing‐
remitting multiple sclerosis (RRMS). It induces protein succination leading to inactivation of …

[HTML][HTML] Dimethyl fumarate: A review of preclinical efficacy in models of neurodegenerative diseases

I Majkutewicz - European Journal of Pharmacology, 2022 - Elsevier
Dimethyl fumarate (DMF) is an antioxidative and anti-inflammatory drug approved for
treatment of multiple sclerosis and psoriasis; however, beneficial effects of DMF have also …

[HTML][HTML] Novel potential pharmacological applications of dimethyl fumarate—an overview and update

G Bresciani, F Manai, S Davinelli, P Tucci… - Frontiers in …, 2023 - frontiersin.org
Dimethyl fumarate (DMF) is an FDA-approved drug for the treatment of psoriasis and
multiple sclerosis. DMF is known to stabilize the transcription factor Nrf2, which in turn …

Dimethyl fumarate in the treatment of relapsing–remitting multiple sclerosis: an overview

R Bomprezzi - Therapeutic advances in neurological …, 2015 - journals.sagepub.com
Multiple sclerosis (MS) shares an immune-mediated origin with psoriasis. Long-term safety
and efficacy data generated in Europe from usage of fumaric acid formulations in the latter …

[HTML][HTML] Utilization of dimethyl fumarate and related molecules for treatment of multiple sclerosis, cancer, and other diseases

Z Al-Jaderi, AA Maghazachi - Frontiers in immunology, 2016 - frontiersin.org
Several drugs have been approved for treatment of multiple sclerosis (MS). Dimethyl
fumarate (DMF) is utilized as an oral drug to treat this disease and is proven to be potent …

[HTML][HTML] Emerging understanding of the mechanism of action for dimethyl fumarate in the treatment of multiple sclerosis

EA Mills, MA Ogrodnik, A Plave… - Frontiers in neurology, 2018 - frontiersin.org
Dimethyl fumarate (DMF) is an effective treatment option for relapsing–remitting multiple
sclerosis (MS), but its therapeutic mechanism of action has not been fully elucidated. A …

Pharmacodynamics of dimethyl fumarate are tissue specific and involve NRF2-dependent and-independent mechanisms

MS Brennan, H Patel, N Allaire, A Thai… - Antioxidants & redox …, 2016 - liebertpub.com
Aims: Gastro-resistant dimethyl fumarate (DMF) is an oral therapeutic indicated for the
treatment of relapsing multiple sclerosis. Recent data suggest that a primary …

Evidence of activation of the Nrf2 pathway in multiple sclerosis patients treated with delayed-release dimethyl fumarate in the Phase 3 DEFINE and CONFIRM studies

S Gopal, A Mikulskis, R Gold, RJ Fox… - Multiple Sclerosis …, 2017 - journals.sagepub.com
Background: Delayed-release dimethyl fumarate (DMF) is an approved oral treatment for
relapsing forms of multiple sclerosis (MS). Preclinical studies demonstrated that DMF …

Dimethyl fumarate: a review of its use in patients with relapsing-remitting multiple sclerosis

CB Burness, ED Deeks - CNS drugs, 2014 - Springer
Dimethyl fumarate (Tecfidera®) is a novel oral therapy that has recently been approved for
the treatment of relapsing forms of multiple sclerosis (MS) and relapsing-remitting MS …

Dimethyl fumarate in relapsing–remitting multiple sclerosis: rationale, mechanisms of action, pharmacokinetics, efficacy and safety

D Dubey, BC Kieseier, HP Hartung… - Expert review of …, 2015 - Taylor & Francis
Dimethyl fumarate (DMF), a fumaric acid ester, is a new orally available disease-modifying
agent that was recently approved by the US FDA and the EMA for the management of …