Systematic review: the effects of long‐term proton pump inhibitor use on serum gastrin levels and gastric histology

L Lundell, M Vieth, F Gibson, P Nagy… - Alimentary …, 2015 - Wiley Online Library
Background Proton pump inhibitors (PPI s) have a well‐established safety profile. However,
concerns have been raised about a potential relationship between PPI‐induced …

Effects of very long (up to 10 years) proton pump blockade on human gastric mucosa

R Lamberts, G Brunner, E Solcia - Digestion, 2001 - karger.com
Background: Long-term use of proton pump inhibitors (PPI) has been reported to worsen
oxyntic mucosa gastritis and the resulting gland atrophy has been considered a potential …

[HTML][HTML] Proton pump inhibitor use, hypergastrinemia, and gastric carcinoids—what is the relationship?

DM McCarthy - International journal of molecular sciences, 2020 - mdpi.com
Neuroendocrine tumors (NETs) throughout the body are the focus of much current interest.
Most occur in the gastrointestinal tract and have shown a major increase in incidence over …

Long‐term proton pump inhibitor (PPI) use and the development of gastric pre‐malignant lesions

H Song, J Zhu, DH Lu - Cochrane Database of Systematic …, 2014 - cochranelibrary.com
Background Proton pump inhibitors (PPIs) are the most effective drugs to reduce gastric acid
secretion. PPIs are one of the most commonly prescribed classes of medications worldwide …

[HTML][HTML] Effect of long-term proton pump inhibitor administration on gastric mucosal atrophy: a meta-analysis

Z Li, C Wu, L Li, Z Wang, H Xie, X He… - Saudi Journal of …, 2017 - journals.lww.com
Materials and Methods: A PubMed search was conducted to identify studies using the
keywords proton pump inhibitors or PPI and gastric atrophy or atrophic gastritis; the …

Meta-analyses: does long-term PPI use increase the risk of gastric premalignant lesions?

L Eslami, S Nasseri-Moghaddam - Archives of Iranian medicine, 2013 - journalaim.com
BACKGROUND: Proton pump inhibitors (PPIs) are the most effective agents available for
reducing acid secretion. They are used for medical treatment of various acid-related …

[HTML][HTML] Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study

KS Cheung, EW Chan, AYS Wong, L Chen, ICK Wong… - Gut, 2018 - gut.bmj.com
Objective Proton pump inhibitors (PPIs) is associated with worsening of gastric atrophy,
particularly in Helicobacter pylori (HP)-infected subjects. We determined the association …

Proton pump inhibitors (PPIs) may cause gastric cancer–clinical consequences

HL Waldum, Ø Sørdal, R Fossmark - Scandinavian journal of …, 2018 - Taylor & Francis
Recently, two epidemiological studies showed that long-term treatment with proton pump
inhibitors (PPIs) increased the risk of gastric cancer. It is well known that hypergastrinemia …

[HTML][HTML] Problems associated with deprescribing of proton pump inhibitors

H Helgadottir, ES Bjornsson - International journal of molecular sciences, 2019 - mdpi.com
Proton pump inhibitors (PPIs) are recommended as a first-line treatment for
gastroesophageal reflux disease (GERD) and other acid related disorders. In recent years …

Long-term use of proton-pump inhibitors and risk of gastric cancer: a review of the current evidence

KS Cheung, WK Leung - Therapeutic advances in …, 2019 - journals.sagepub.com
Gastric cancer remains one of the leading cancers in the world with a high mortality,
particularly in East Asia. Helicobacter pylori infection accounts for the majority of the …