In this study, a series of novel 1, 3, 4-oxadiazole-benzimidazole derivatives were designed
and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF …

In this study, a series of imidazole derivatives was designed, synthesized, and evaluated for
in vitro biological activity on the human breast cancer cell line MCF7 by MTT assay. To …

Breast cancer is the most frequent female cancer and second cause of cancer-related
deaths among women around the world. Two thirds of breast cancer patients have hormone …

In the search for novel aromatase inhibitors, a series of triazole and imidazole-based
carbamate derivatives were designed and synthesized. Final compounds were thus …

In this study, some new thiosemicarbazide and their corresponding 1, 3, 4-thiadiazole
derivatives containing pyridine nuclei were synthesized. Their structures were established …

Breast cancer is one of the leading causes of death noticed in women across the world. Of
late the most successful treatments rendered are the use of aromatase inhibitors (AIs). In the …

A recent discovery of aromatase crystal structure triggered the efforts to design novel
aromatase inhibitors for breast cancer therapy. While correlating docking scores with …

Estrogen is a significant factor in the maintenance and progression of hormone-dependent
breast cancer. As well known, aromatase mediates the production of estrogen. Thus …

Inhibition of aromatase enzymes is very important in the prevention of estrogen-related
diseases and the regulation of estrogen levels. Aromatase enzyme is involved in the final …

Considering the potent cytotoxic activities of hybrid benzofuran–imidazolium and
quinazolinone derivatives on the breast cancer cell line MCF-7, novel hybrid derivatives …