Infectious diseases are the second leading cause of death worldwide. Although the host
multitropism of some pathogens has rendered their manipulation possible in animal models …

The interaction of bacterial pathogens with their hosts' innate immune systems can be
extremely complex and is often difficult to disentangle experimentally. Using mouse models …

Outbreaks of emerging infectious diseases pose a serious threat to public health security,
human health and economic development. After an outbreak, an animal model for an …

Mouse genetics is a powerful tool for the dissection of genes, proteins, and pathways
important in biological processes. Application of this approach to study the host response to …

Host genetic variation has a major impact on infectious disease susceptibility. The study of
pathogen resistance genes, largely aided by mouse models, has significantly advanced our …

Genetic factors strongly determine the outcome of infectious diseases caused by various
pathogens. The molecular mechanisms of resistance and susceptibility in humans, however …

Individuals vary in their susceptibility to infectious disease, and it is now well established that
host genetic factors form a major component of this variation. The discovery of genes …

The laboratory mouse has proved an invaluable model to identify host factors that regulate
the progression and outcome of virus-induced disease. The paradigm is to use single-gene …

Laboratory mice often exhibit wide differences in susceptibility when infected experimentally
with viruses. Based on such observations, experiments have been designed to investigate …

Most species seem to be completely resistant to most pathogens and parasites. This
resistance has been called “nonhost resistance” because it is exhibited by species that are …