Spray freeze-drying as an alternative to the ionic gelation method to produce chitosan and alginate nano-particles targeted to the colon
A Gamboa, V Araujo, N Caro, M Gotteland… - Journal of …, 2015 - Elsevier
Chitosan and alginate nano-composite (NP) carriers intended for colonic delivery containing
prednisolone and inulin were obtained by two processes. Spray freeze-drying using …
prednisolone and inulin were obtained by two processes. Spray freeze-drying using …
Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery
Putative colonic release formulations of calcium (Ca)-alginate coated with chitosan
containing two different actives, prednisolone and inulin, were prepared in three different …
containing two different actives, prednisolone and inulin, were prepared in three different …
Chitosan coated Ca–alginate microparticles loaded with budesonide for delivery to the inflamed colonic mucosa
Using a novel one-step spray-drying process uncoated and Eudragit® S 100 coated
chitosan–Ca–alginate microparticles efficiently loaded with budesonide (BDS), with …
chitosan–Ca–alginate microparticles efficiently loaded with budesonide (BDS), with …
Chitosan/polyethylene glycol beads crosslinked with tripolyphosphate and glutaraldehyde for gastrointestinal drug delivery
T Buranachai, N Praphairaksit, N Muangsin - Aaps Pharmscitech, 2010 - Springer
This study reports on the preparation of chitosan (CS)/polyethylene glycol (PEG) hydrogel
beads using sodium diclofenac (DFNa) as a model drug. Following the optimization of the …
beads using sodium diclofenac (DFNa) as a model drug. Following the optimization of the …
Recent advances in colon drug delivery systems
R Arévalo-Pérez, C Maderuelo, JM Lanao - Journal of controlled release, 2020 - Elsevier
As a result of its ability to target certain drugs and/or peptides to the colonic region for the
treatment of several diseases while avoiding systemic absorption and potential side effects …
treatment of several diseases while avoiding systemic absorption and potential side effects …
Colon delivery of prednisolone based on chitosan coated polysaccharide tablets
HS Park, JY Lee, SH Cho, HJ Baek, SJ Lee - Archives of pharmacal …, 2002 - Springer
Colon drug delivery is advantageous in the treatment of colonic disease and oral delivery of
drugs unstable or suceptible to enzymatic degradation in upper Gl tract. In this study …
drugs unstable or suceptible to enzymatic degradation in upper Gl tract. In this study …
A novel dissolution media for testing drug release from a nanostructured polysaccharide-based colon specific drug delivery system: an approach to alternative colon …
The aim of this study was to develop a novel microbially triggered and animal-sparing
dissolution method for testing of nanorough polysaccharide-based micron granules for …
dissolution method for testing of nanorough polysaccharide-based micron granules for …
Chitosan–chondroitin sulfate based matrix tablets for colon specific delivery of indomethacin
JR Amrutkar, SG Gattani - AAPS pharmscitech, 2009 - Springer
The different approaches for targeting orally administered drugs to the colon include coating
with pH-dependent polymers, design of time-release dosage forms, and the utilization of …
with pH-dependent polymers, design of time-release dosage forms, and the utilization of …
Freeze dried chitosan/poly-(glutamic acid) microparticles for intestinal delivery of lansoprazole
M Nand Singh, H KS Yadav, M Ram… - Current drug …, 2012 - ingentaconnect.com
Lansoprazole sodium is a proton pump inhibitor used in treating gastroesophageal reflux
disease (GERD). It is highly acid-labile and presents many formulation challenges …
disease (GERD). It is highly acid-labile and presents many formulation challenges …
Studies of chitosan/organic acid/Eudragit® RS/RL-coated system for colonic delivery
K Kaur, K Kim - International Journal of Pharmaceutics, 2009 - Elsevier
Prednisolone (PDS) beads were coated sequentially with (i) innermost hydrophobic layer of
Eudragit® RS/RL,(ii) middle drug release-triggering layer of chitosan, organic acid and …
Eudragit® RS/RL,(ii) middle drug release-triggering layer of chitosan, organic acid and …