Spray freeze-drying as an alternative to the ionic gelation method to produce chitosan and alginate nano-particles targeted to the colon

A Gamboa, V Araujo, N Caro, M Gotteland… - Journal of …, 2015 - Elsevier
Chitosan and alginate nano-composite (NP) carriers intended for colonic delivery containing
prednisolone and inulin were obtained by two processes. Spray freeze-drying using …

Release of prednisolone and inulin from a new calcium-alginate chitosan-coated matrix system for colonic delivery

V Araujo, A Gamboa, N Caro, L Abugoch… - Journal of …, 2013 - Elsevier
Putative colonic release formulations of calcium (Ca)-alginate coated with chitosan
containing two different actives, prednisolone and inulin, were prepared in three different …

Chitosan coated Ca–alginate microparticles loaded with budesonide for delivery to the inflamed colonic mucosa

MS Crcarevska, MG Dodov, K Goracinova - European Journal of …, 2008 - Elsevier
Using a novel one-step spray-drying process uncoated and Eudragit® S 100 coated
chitosan–Ca–alginate microparticles efficiently loaded with budesonide (BDS), with …

Chitosan/polyethylene glycol beads crosslinked with tripolyphosphate and glutaraldehyde for gastrointestinal drug delivery

T Buranachai, N Praphairaksit, N Muangsin - Aaps Pharmscitech, 2010 - Springer
This study reports on the preparation of chitosan (CS)/polyethylene glycol (PEG) hydrogel
beads using sodium diclofenac (DFNa) as a model drug. Following the optimization of the …

Recent advances in colon drug delivery systems

R Arévalo-Pérez, C Maderuelo, JM Lanao - Journal of controlled release, 2020 - Elsevier
As a result of its ability to target certain drugs and/or peptides to the colonic region for the
treatment of several diseases while avoiding systemic absorption and potential side effects …

Colon delivery of prednisolone based on chitosan coated polysaccharide tablets

HS Park, JY Lee, SH Cho, HJ Baek, SJ Lee - Archives of pharmacal …, 2002 - Springer
Colon drug delivery is advantageous in the treatment of colonic disease and oral delivery of
drugs unstable or suceptible to enzymatic degradation in upper Gl tract. In this study …

A novel dissolution media for testing drug release from a nanostructured polysaccharide-based colon specific drug delivery system: an approach to alternative colon …

NG Kotla, S Singh, B Maddiboyina… - International Journal …, 2016 - Taylor & Francis
The aim of this study was to develop a novel microbially triggered and animal-sparing
dissolution method for testing of nanorough polysaccharide-based micron granules for …

Chitosan–chondroitin sulfate based matrix tablets for colon specific delivery of indomethacin

JR Amrutkar, SG Gattani - AAPS pharmscitech, 2009 - Springer
The different approaches for targeting orally administered drugs to the colon include coating
with pH-dependent polymers, design of time-release dosage forms, and the utilization of …

Freeze dried chitosan/poly-(glutamic acid) microparticles for intestinal delivery of lansoprazole

M Nand Singh, H KS Yadav, M Ram… - Current drug …, 2012 - ingentaconnect.com
Lansoprazole sodium is a proton pump inhibitor used in treating gastroesophageal reflux
disease (GERD). It is highly acid-labile and presents many formulation challenges …

Studies of chitosan/organic acid/Eudragit® RS/RL-coated system for colonic delivery

K Kaur, K Kim - International Journal of Pharmaceutics, 2009 - Elsevier
Prednisolone (PDS) beads were coated sequentially with (i) innermost hydrophobic layer of
Eudragit® RS/RL,(ii) middle drug release-triggering layer of chitosan, organic acid and …