[HTML][HTML] NLRP3 inflammasome in neurological diseases, from functions to therapies
L Song, L Pei, S Yao, Y Wu, Y Shang - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …
[HTML][HTML] Focus on the role of the NLRP3 inflammasome in multiple sclerosis: pathogenesis, diagnosis, and therapeutics
Y Cui, H Yu, Z Bu, L Wen, L Yan, J Feng - Frontiers in Molecular …, 2022 - frontiersin.org
Neuroinflammation is initiated with an aberrant innate immune response in the central
nervous system (CNS) and is involved in many neurological diseases. Inflammasomes are …
nervous system (CNS) and is involved in many neurological diseases. Inflammasomes are …
[HTML][HTML] Key mechanisms and potential targets of the NLRP3 inflammasome in neurodegenerative diseases
Y Guan, F Han - Frontiers in Integrative Neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases are neuronal disorders characterized by the loss of a large
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …
Recent advances of the NLRP3 inflammasome in central nervous system disorders
K Zhou, L Shi, Y Wang, S Chen… - Journal of Immunology …, 2016 - Wiley Online Library
Inflammasomes are multiprotein complexes that trigger the activation of caspases‐1 and
subsequently the maturation of proinflammatory cytokines interleukin‐1β and interleukin‐18 …
subsequently the maturation of proinflammatory cytokines interleukin‐1β and interleukin‐18 …
[HTML][HTML] The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases
YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Biomedicine & …, 2021 - Elsevier
In an ageing society, neurodegenerative diseases have attracted attention because of their
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …
[HTML][HTML] Targeting NLRP3 inflammasome in translational treatment of nervous system diseases: an update
Q Yu, T Zhao, M Liu, D Cao, J Li, Y Li, M Xia… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammatory response is the immune response mechanism of the innate immune
system of the central nervous system. Both primary and secondary injury can activate …
system of the central nervous system. Both primary and secondary injury can activate …
[HTML][HTML] Targeting NLRP3 inflammasome in the treatment of CNS diseases
BZ Shao, Q Cao, C Liu - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Central nervous system (CNS) is one of the largest killers of people's health all over the
world. The overactivation of the immune and inflammatory responses is considered as an …
world. The overactivation of the immune and inflammatory responses is considered as an …
NLRP3 inflammasome in neurodegenerative disease
FL Anderson, KE Biggs, BE Rankin, MC Havrda - Translational Research, 2023 - Elsevier
Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …
microenvironment, culminating in functional deficits resulting from neuronal cell death …
[HTML][HTML] The roles of the NLRP3 inflammasome in neurodegenerative and metabolic diseases and in relevant advanced therapeutic interventions
Inflammasomes are intracellular multiprotein complexes in the cytoplasm that regulate
inflammation activation in the innate immune system in response to pathogens and to host …
inflammation activation in the innate immune system in response to pathogens and to host …
The NLRP3 inflammasome: a new player in neurological diseases
Inflammasomes are supramolecular protein complexes implicated in the detection of
pathogens or danger-associated molecules and are responsible for mounting the first line of …
pathogens or danger-associated molecules and are responsible for mounting the first line of …