[HTML][HTML] NLRP3 inflammasome in neurological diseases, from functions to therapies

L Song, L Pei, S Yao, Y Wu, Y Shang - Frontiers in cellular …, 2017 - frontiersin.org
Neuroinflammation has been identified as a causative factor of multiple neurological
diseases. The nucleotide-binding oligomerization domain-, leucine-rich repeat-and pyrin …

[HTML][HTML] Focus on the role of the NLRP3 inflammasome in multiple sclerosis: pathogenesis, diagnosis, and therapeutics

Y Cui, H Yu, Z Bu, L Wen, L Yan, J Feng - Frontiers in Molecular …, 2022 - frontiersin.org
Neuroinflammation is initiated with an aberrant innate immune response in the central
nervous system (CNS) and is involved in many neurological diseases. Inflammasomes are …

[HTML][HTML] Key mechanisms and potential targets of the NLRP3 inflammasome in neurodegenerative diseases

Y Guan, F Han - Frontiers in Integrative Neuroscience, 2020 - frontiersin.org
Neurodegenerative diseases are neuronal disorders characterized by the loss of a large
number of neurons in the human brain. Innate immunity-mediated neuroinflammation …

Recent advances of the NLRP3 inflammasome in central nervous system disorders

K Zhou, L Shi, Y Wang, S Chen… - Journal of Immunology …, 2016 - Wiley Online Library
Inflammasomes are multiprotein complexes that trigger the activation of caspases‐1 and
subsequently the maturation of proinflammatory cytokines interleukin‐1β and interleukin‐18 …

[HTML][HTML] The involvement of NLRP3 inflammasome in the treatment of neurodegenerative diseases

YS Feng, ZX Tan, LY Wu, F Dong, F Zhang - Biomedicine & …, 2021 - Elsevier
In an ageing society, neurodegenerative diseases have attracted attention because of their
high incidence worldwide. Despite extensive research, there is a lack of conclusive insights …

[HTML][HTML] Targeting NLRP3 inflammasome in translational treatment of nervous system diseases: an update

Q Yu, T Zhao, M Liu, D Cao, J Li, Y Li, M Xia… - Frontiers in …, 2021 - frontiersin.org
Neuroinflammatory response is the immune response mechanism of the innate immune
system of the central nervous system. Both primary and secondary injury can activate …

[HTML][HTML] Targeting NLRP3 inflammasome in the treatment of CNS diseases

BZ Shao, Q Cao, C Liu - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Central nervous system (CNS) is one of the largest killers of people's health all over the
world. The overactivation of the immune and inflammatory responses is considered as an …

NLRP3 inflammasome in neurodegenerative disease

FL Anderson, KE Biggs, BE Rankin, MC Havrda - Translational Research, 2023 - Elsevier
Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …

[HTML][HTML] The roles of the NLRP3 inflammasome in neurodegenerative and metabolic diseases and in relevant advanced therapeutic interventions

RH Pirzada, N Javaid, S Choi - Genes, 2020 - mdpi.com
Inflammasomes are intracellular multiprotein complexes in the cytoplasm that regulate
inflammation activation in the innate immune system in response to pathogens and to host …

The NLRP3 inflammasome: a new player in neurological diseases

E Eren, N Özören - Turkish Journal of Biology, 2019 - journals.tubitak.gov.tr
Inflammasomes are supramolecular protein complexes implicated in the detection of
pathogens or danger-associated molecules and are responsible for mounting the first line of …