The essential function of the circulatory system is to continuously and efficiently supply the
O2 and nutrients necessary to meet the metabolic demands of every cell in the body, a …

The vast majority of the brain's vascular length is composed of capillaries, where our
understanding of blood flow control remains incomplete. This review synthesizes current …

Despite the abundance of capillary thin-strand pericytes and their proximity to neurons and
glia, little is known of the contributions of these cells to the control of brain hemodynamics …

The majority of the brain's vasculature is composed of intricate capillary networks lined by
capillary pericytes. However, it remains unclear whether capillary pericytes influence blood …

Spreading depolarization is assumed to be the mechanism of migraine with aura, which is
accompanied by an initial predominant hyperaemic response followed by persistent …

Modern functional imaging techniques of the brain measure local hemodynamic responses
evoked by neuronal activity. Capillary pericytes recently were suggested to mediate …

The cerebral circulation is highly specialized, both structurally and functionally, and it
provides a fine-tuned supply of oxygen and nutrients to active regions of the brain. Our …

Pericytes, spatially isolated contractile cells on capillaries, have been reported to control
cerebral blood flow physiologically, and to limit blood flow after ischaemia by constricting …

Pericytes are mural cells with contractile properties. Here, we provide evidence that
microvascular pericytes modulate cerebral blood flow in response to neuronal activity …

Pericytes, attached to the surface of capillaries, play an important role in regulating local
blood flow. Using optogenetic tools and genetically encoded reporters in conjunction with …