The impact of ageing in innate immunity is poorly understood. Studies in the mouse model
have described altered innate immune functions in aged macrophages, although these were …

Elderly individuals display increased susceptibility to chronic inflammatory diseases and
microbial infections, such as periodontitis and oral aspiration pneumonia. The resurgent …

The elderly exhibit increased susceptibility to a number of inflammatory or degenerative
pathologies. Aging is similarly thought to be associated with increased prevalence and …

Innate and adaptive immune functions decline with age, leading to increased susceptibility
to infectious diseases and cancer, and reduced responses to preventive vaccination in the …

Advanced age is associated with a breakdown of the epithelial barriers of the skin, lung and
gastrointestinal tract, which enables invasion of delicate mucosal tissues by pathogenic …

Periodontal disease is a chronic inflammatory condition that results in the destruction of the
teeth supporting tissues, eventually leading to the loss of teeth and reduced quality of life. In …

A fully functioning immune system is essential in order to maintain good health. However,
the immune system deteriorates with advancing age, and this contributes to increased …

The cellular changes during ageing are incompletely understood yet immune system
dysfunction is implicated in the age-related decline in health. The acquired immune system …

As we age, the innate immune system becomes dysregulated and is characterized by
persistent inflammatory responses that involve multiple immune and non-immune cell types …

Aging affects every innate immune cell, including changes in cell numbers and function.
Defects in the function of some cells are intrinsic, whereas for other cells, defects are …