The aim of the present study was to investigate whether methylation of the angiotensin I
converting enzyme 2 (ACE2) promoter increases the risk of essential hypertension (EH). A …

The purpose of the present study was to investigate whether methylation of the angiotensin II
type 1 receptor (AGTR1) promoter contributed to the risk of essential hypertension (EH). A …

The potential effects of the interactions between DNA methylation (CpG1 and CpG2-5
methylation levels) of the α-adducin (ADD1) gene promoter and ADD1 tagSNPs (tag single …

Physical, chemical, and social environments adversely affect the molecular process and
results in cell signal transduction and the subsequent transcription factor dysregulation …

Objectives: The present study aimed to evaluate the hypertension status of community
residents, analyze environmental and epigenetic factors, and propose prevention measures …

The goal of our study is to investigate the contribution of promoter DNA methylation of α-
adducin (ADD1) gene to the risk of essential hypertension (EH). Using the bisulphite …

Essential hypertension (EH) is commonly accompanied by a dysfunction of glucose
metabolism. Glucokinase (GCK) is a key enzyme involved in glucose metabolism. The aim …

The amiloride-sensitive sodium channel beta subunit (SCNN1B) gene encodes the beta
subunit of the epithelial sodium channel, which is involved in blood pressure homeostasis …

Background The angiotensin converting enzyme (ACE) has been repeatedly discussed as
susceptibility factor for major depression (MD) and the bi-directional relation between MD …

Epigenetic mechanisms might play a role in the pathophysiology of hypertension, a major
risk factor for cardiovascular disease and renal failure. We aimed to systematically review …