[HTML][HTML] How efficient are alendronate-nano/biomaterial combinations for anti-osteoporosis therapy? An evidence-based review of the literature

J Klara, J Lewandowska-Łańcucka - International journal of …, 2022 - ncbi.nlm.nih.gov
Osteoporosis is defined as a systemic skeletal disease characterized by low bone mass and
microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility …

[HTML][HTML] Nano-based biomaterials as drug delivery systems against osteoporosis: a systematic review of preclinical and clinical evidence

F Salamanna, A Gambardella, D Contartese, A Visani… - Nanomaterials, 2021 - mdpi.com
Osteoporosis (OP) is one of the most significant causes of morbidity, particularly in post-
menopausal women and older men. Despite its remarkable occurrence, the search for an …

Emerging nano-scale delivery systems for the treatment of osteoporosis

AP Dayanandan, WJ Cho, H Kang, AB Bello… - Biomaterials …, 2023 - spj.science.org
Osteoporosis is a pathological condition characterized by an accelerated bone resorption
rate, resulting in decreased bone density and increased susceptibility to fractures …

[HTML][HTML] Bone diseases: Current approach and future perspectives in drug delivery systems for bone targeted therapeutics

G Chindamo, S Sapino, E Peira, D Chirio… - Nanomaterials, 2020 - mdpi.com
Bone diseases include a wide group of skeletal-related disorders that cause mobility
limitations and mortality. In some cases, eg, in osteosarcoma (OS) and metastatic bone …

Nanotechnology for targeted drug delivery to treat osteoporosis

M Kaur, M Nagpal, G Aggarwal - Current Drug Targets, 2023 - ingentaconnect.com
Bone diseases such as rheumatoid arthritis, Paget's disease, and osteoporosis cause
mortality and mobility limits. Nanomedicine and nano delivery systems have been utilised to …

Dual targeting anti-osteoporotic therapy through potential nanotherapeutic approaches

S Salave, D Rana, D Benival - Pharmaceutical Nanotechnology, 2022 - ingentaconnect.com
Osteoporosis is characterised by a major public health burden, particularly taking into
account the ageing global population. Therapeutic modalities for osteoporosis are …

In vitro/ex vivo evaluation of multifunctional collagen/chitosan/hyaluronic acid hydrogel-based alendronate delivery systems

J Klara, A Hinz, M Bzowska, W Horak… - International Journal of …, 2024 - Elsevier
Injectable hydrogel-based materials have emerged as promising alendronate (ALN) delivery
systems for the treatment of osteoporosis. However, their intrinsic permeability limits the …

Alendronate-decorated nanoparticles as bone-targeted alendronate carriers for potential osteoporosis treatment

C Jing, B Li, H Tan, C Zhang, H Liang… - ACS Applied Bio …, 2021 - ACS Publications
Osteoporosis is a skeletal disorder characterized by a low bone mass and density.
Alendronate (Alen), a second-generation bisphosphonate drug, was indicated as the first …

[HTML][HTML] Towards controlling the local bone tissue remodeling—multifunctional injectable composites for osteoporosis treatment

J Klara, S Onak, A Kowalczyk, W Horak… - International Journal of …, 2023 - mdpi.com
Alendronate (ALN) is the most commonly prescribed oral nitrogen-containing
bisphosphonate for osteoporosis therapy. However, its administration is associated with …

Enteric-coated alendronate sodium nanoliposomes: a novel formula to overcome barriers for the treatment of osteoporosis

KM Hosny, OAA Ahmed… - Expert opinion on drug …, 2013 - Taylor & Francis
Background and objectives: Alendronate sodium (ALS) is the most common drug used for
the treatment of osteoporosis. The challenges facing ALS use include: very poor oral …