Six-month effective treatment of corneal graft rejection

T Meng, J Zheng, M Chen, Y Zhao, H Sudarjat… - Science …, 2023 - science.org
Topical corticosteroid eye drop is the mainstay for preventing and treating corneal graft
rejection. While the frequent topical corticosteroid use is associated with risk of intraocular …

Corticosteroid-loaded biodegradable nanoparticles for prevention of corneal allograft rejection in rats

Q Pan, Q Xu, NJ Boylan, NW Lamb, DG Emmert… - Journal of controlled …, 2015 - Elsevier
Immunologic graft rejection is one of the main causes of short and long-term graft failure in
corneal transplantation. Steroids are the most commonly used immunosuppressive agents …

A biodegradable, sustained-released, prednisolone acetate microfilm drug delivery system effectively prolongs corneal allograft survival in the rat keratoplasty model

YC Liu, Y Peng, NC Lwin, SS Venkatraman, TT Wong… - PloS one, 2013 - journals.plos.org
Frequent and long-term use of topical corticosteroids after corneal transplantation is
necessary to prevent graft rejection. However, it relies heavily on patient compliance, and …

Controlled release of dexamethasone sodium phosphate with biodegradable nanoparticles for preventing experimental corneal neovascularization

B Wang, Y Tang, Y Oh, NW Lamb, S Xia, Z Ding… - … , Biology and Medicine, 2019 - Elsevier
Corneal neovascularization (CNV) leads to the loss of corneal transparency and vision
impairment, and can ultimately cause blindness. Topical corticosteroids are the first line …

The use of combined intravenous pulse methylprednisolone and oral cyclosporin A in the treatment of corneal graft rejection: a preliminary study

DSC Lam, AKK Wong, CCY Tham, ATS Leung - Eye, 1998 - nature.com
Purpose Oral cyclosporin A used in addition to high-dose intravenous pulse
methylprednisolone has been shown to have an adjunctive effect in reversing the rejection …

Effects of subconjunctival ranibizumab in a presensitized rat model of corneal graft

KJ Cho, JS Choi, MY Choi, CK Joo - Experimental eye research, 2013 - Elsevier
We evaluated whether corneal graft survival in presensitized corneal transplantation was
affected by subconjunctival ranibizumab in a rat model. The effect of ranibizumab in the …

[HTML][HTML] Management of corneal graft rejection–a case series report and review of the literature

P Nguyen, F Barte, S Shinada… - Journal of clinical & …, 2010 - ncbi.nlm.nih.gov
Management of Corneal Graft Rejection – A Case Series Report and Review of the Literature -
PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI …

Corneal graft rejection: recent updates

VMB Tham, RL Abbott - International ophthalmology clinics, 2002 - journals.lww.com
In 2000, nearly 47,000 corneal transplantations were performed in the United States, making
penetrating keratoplasty one of the most common human tissue transplantation procedures …

Prevention and treatment of corneal graft rejection: current practice patterns of the Cornea Society (2011)

B Kharod-Dholakia, JB Randleman, JG Bromley… - Cornea, 2015 - journals.lww.com
Purpose: To analyze current practice patterns in the prevention and treatment of corneal
graft rejection for both penetrating keratoplasty (PK) and endothelial keratoplasty (EK) and to …

Suppression of graft rejection using 15-deoxyspergualin in the allogeneic rat penetrating keratoplasty model

EJ Holland, TW Olsen, J Sterrer, JM Ketchum… - Cornea, 1994 - journals.lww.com
We tested the ability of 15-deoxyspergualin (DSG), a new immunosuppressant, to inhibit
corneal allograft rejection in the rat penetrating keratoplasty model. Fifty-six inbred Lewis …