[HTML][HTML] Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus

V Vasilkov, B Caswell-Midwinter, Y Zhao… - Scientific Reports, 2023 - nature.com
Tinnitus, reduced sound-level tolerance, and difficulties hearing in noisy environments are
the most common complaints associated with sensorineural hearing loss in adult …

High-frequency tinnitus without hearing loss does not mean absence of deafferentation

N Weisz, T Hartmann, K Dohrmann, W Schlee… - Hearing research, 2006 - Elsevier
A broad consensus within the neuroscience of tinnitus holds that this audiologic condition is
triggered by central deafferentation, mostly due to cochlear damage. The absence of …

Tinnitus with a normal audiogram: physiological evidence for hidden hearing loss and computational model

R Schaette, D McAlpine - Journal of Neuroscience, 2011 - Soc Neuroscience
Ever since Pliny the Elder coined the term tinnitus, the perception of sound in the absence of
an external sound source has remained enigmatic. Traditional theories assume that tinnitus …

[HTML][HTML] Tinnitus with a normal audiogram: Relation to noise exposure but no evidence for cochlear synaptopathy

H Guest, KJ Munro, G Prendergast, S Howe, CJ Plack - Hearing research, 2017 - Elsevier
In rodents, exposure to high-level noise can destroy synapses between inner hair cells and
auditory nerve fibers, without causing hair cell loss or permanent threshold elevation. Such …

[HTML][HTML] Tinnitus-related dissociation between cortical and subcortical neural activity in humans with mild to moderate sensorineural hearing loss

K Boyen, E de Kleine, P van Dijk, DRM Langers - Hearing research, 2014 - Elsevier
Tinnitus is a phantom sound percept that is strongly associated with peripheral hearing loss.
However, only a fraction of hearing-impaired subjects develops tinnitus. This may be based …

Tinnitus and auditory perception after a history of noise exposure: Relationship to auditory brainstem response measures

NF Bramhall, D Konrad-Martin, GP McMillan - Ear and hearing, 2018 - journals.lww.com
Objectives: To determine whether auditory brainstem response (ABR) wave I amplitude is
associated with measures of auditory perception in young people with normal distortion …

[HTML][HTML] Comparisons of auditory brainstem response and sound level tolerance in tinnitus ears and non-tinnitus ears in unilateral tinnitus patients with normal …

HJ Shim, YH An, DH Kim, JE Yoon, JH Yoon - PloS one, 2017 - journals.plos.org
Objective Recently,“hidden hearing loss” with cochlear synaptopathy has been suggested
as a potential pathophysiology of tinnitus in individuals with a normal hearing threshold …

[HTML][HTML] Tinnitus and patterns of hearing loss

CM Tan, W Lecluyse, D McFerran, R Meddis - Journal of the Association …, 2013 - Springer
Tinnitus is strongly linked with the presence of damaged hearing. However, it is not known
why tinnitus afflicts only some, and not all, hearing-impaired listeners. One possibility is that …

Weak middle-ear-muscle reflex in humans with noise-induced tinnitus and normal hearing may reflect cochlear synaptopathy

M Wojtczak, JA Beim, AJ Oxenham - ENeuro, 2017 - eneuro.org
Chronic tinnitus is a prevalent hearing disorder, and yet no successful treatments or
objective diagnostic tests are currently available. The aim of this study was to investigate the …

Electrophysiological markers of cochlear function correlate with hearing-in-noise performance among audiometrically normal subjects

KJ Grant, AM Mepani, P Wu… - Journal of …, 2020 - journals.physiology.org
Hearing loss caused by noise exposure, ototoxic drugs, or aging results from the loss of
sensory cells, as reflected in audiometric threshold elevation. Animal studies show that loss …