Congenital muscular dystrophy caused by laminin α2 chain deficiency (also known as
MDC1A) is a severe and incapacitating disease, characterized by massive muscle wasting …

Muscle atrophy, a significant characteristic of congenital muscular dystrophy with laminin α2
chain deficiency (also known as MDC1A), occurs by a change in the normal balance …

Several approaches to treat laminin α2 chain–deficient congenital muscular dystrophy
(MDC1A) in mouse models have been undertaken. Most have shown promising results in …

Congenital muscular dystrophy with laminin α2 chain deficiency (MDC1A) is one of the most
severe forms of muscular disease and is characterized by severe muscle weakness and …

Laminin-211 is a major constituent of the skeletal muscle basement membrane. It stabilizes
skeletal muscle and influences signal transduction events from the myomatrix to the muscle …

MDC1A, the second most prevalent form of congenital muscular dystrophy, results from
laminin-α2 chain deficiency. This disease is characterized by extensive muscle wasting that …

The most common form of human congenital muscular dystrophy (CMD) is caused by
mutations in the laminin-α2 gene. Loss of laminin-α2 function in this autosomal recessive …

A number of recent studies have highlighted the importance of autophagy and the ubiquitin-
proteasome in the pathogenesis of muscle wasting in different types of inherited muscle …

Absence of laminin α2 chain leads to a severe form of congenital muscular dystrophy
(MDC1A) associated with peripheral neuropathy. Hence, future therapies should be aimed …

Merosin-deficient congenital muscular dystrophy type 1A (MDC1A) is a severe and fatal
muscle-wasting disease with no cure. MDC1A patients and the dyW−/− mouse model exhibit …