Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels

W Lu, YC Cheng, K Chen, H Wang… - Human molecular …, 2015 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …

Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …

MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …

Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians

MB Lanktree, SS Anand, S Yusuf… - Circulation …, 2010 - Am Heart Assoc
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …

[HTML][HTML] A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms [S]

S Mack, S Coassin, R Rueedi, NA Yousri… - Journal of lipid …, 2017 - ASBMB
High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …

A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk

T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …

Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report

M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …

[HTML][HTML] Genome-wide association study of plasma lipoprotein (a) levels identifies multiple genes on chromosome 6q [S]

C Ober, AS Nord, EE Thompson, L Pan, Z Tan… - Journal of lipid …, 2009 - ASBMB
Plasma lipoprotein (a)(Lp [a]) level is an independent risk factor of cardiovascular disease
that is under strong genetic control. We conducted a genome-wide association study of …

Lipoprotein (a): genotype–phenotype relationship and impact on atherogenic risk

B Enkhmaa, E Anuurad, W Zhang, T Tran… - … syndrome and related …, 2011 - liebertpub.com
In 2010, more than 45 years after the initial discovery of lipoprotein (a)[Lp (a)] by Kare Berg,
an European Atherosclerosis Society Consensus Panel recommended screening for …

Genetics of plasma lipoprotein (a) concentrations

E Boerwinkle - Current Opinion in Lipidology, 1992 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is a low-density-like lipoprotein with the addition of a Lp (a)-
specific protein, apolipoprotein (a)[apo (a)]. Plasma concentrations of Lp (a) are a risk factor …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …