Evidence for several independent genetic variants affecting lipoprotein (a) cholesterol levels
W Lu, YC Cheng, K Chen, H Wang… - Human molecular …, 2015 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is an independent risk factor for atherosclerosis-related
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
events that is under strong genetic control (heritability= 0.68–0.98). However, causal …
Genome-Wide Association Study and Identification of a Protective Missense Variant on Lipoprotein (a) Concentration: Protective Missense Variant on Lipoprotein (a) …
MA Said, MW Yeung, YJ van de Vegte… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lipoprotein (a)(Lp [a]) is associated with coronary artery disease (CAD) but also
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
to LDL (low-density lipoprotein) cholesterol. The genetic architecture of Lp (a) remains …
Comprehensive Analysis of Genomic Variation in the LPA Locus and Its Relationship to Plasma Lipoprotein(a) in South Asians, Chinese, and European Caucasians
Background—Functional copy number variation in the apolipoprotein (a) gene (LPA)
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
underlies a variable number of protein kringle domains repeated in tandem in the lipoprotein …
[HTML][HTML] A genome-wide association meta-analysis on lipoprotein (a) concentrations adjusted for apolipoprotein (a) isoforms [S]
High lipoprotein (a)[Lp (a)] concentrations are an independent risk factor for cardiovascular
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …
outcomes. Concentrations are strongly influenced by apo (a) kringle IV repeat isoforms. We …
A Common LPA Null Allele Associates With Lower Lipoprotein(a) Levels and Coronary Artery Disease Risk
T Kyriakou, U Seedorf, A Goel… - … , and vascular biology, 2014 - Am Heart Assoc
Objective—Increased levels of lipoprotein (a) are a highly heritable risk factor for coronary
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
artery disease (CAD). The genetic determinants of lipoprotein (a) levels are mainly because …
Genome-Wide Association Study Highlights APOH as a Novel Locus for Lipoprotein(a) Levels—Brief Report
M Hoekstra, HY Chen, J Rong, L Dufresne… - … , and vascular biology, 2021 - Am Heart Assoc
Objective: Lp (a)(lipoprotein [a]) is an independent risk factor for cardiovascular diseases
and plasma levels are primarily determined by variation at the LPA locus. We performed a …
and plasma levels are primarily determined by variation at the LPA locus. We performed a …
[HTML][HTML] Genome-wide association study of plasma lipoprotein (a) levels identifies multiple genes on chromosome 6q [S]
Plasma lipoprotein (a)(Lp [a]) level is an independent risk factor of cardiovascular disease
that is under strong genetic control. We conducted a genome-wide association study of …
that is under strong genetic control. We conducted a genome-wide association study of …
Lipoprotein (a): genotype–phenotype relationship and impact on atherogenic risk
B Enkhmaa, E Anuurad, W Zhang, T Tran… - … syndrome and related …, 2011 - liebertpub.com
In 2010, more than 45 years after the initial discovery of lipoprotein (a)[Lp (a)] by Kare Berg,
an European Atherosclerosis Society Consensus Panel recommended screening for …
an European Atherosclerosis Society Consensus Panel recommended screening for …
Genetics of plasma lipoprotein (a) concentrations
E Boerwinkle - Current Opinion in Lipidology, 1992 - journals.lww.com
Abstract Lipoprotein (a)[Lp (a)] is a low-density-like lipoprotein with the addition of a Lp (a)-
specific protein, apolipoprotein (a)[apo (a)]. Plasma concentrations of Lp (a) are a risk factor …
specific protein, apolipoprotein (a)[apo (a)]. Plasma concentrations of Lp (a) are a risk factor …
[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene
S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …