Bayesian detection of expression quantitative trait loci hot spots
High-throughput genomics allows genome-wide quantification of gene expression levels in
tissues and cell types and, when combined with sequence variation data, permits the …
tissues and cell types and, when combined with sequence variation data, permits the …
A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies
Gene expression measurements are influenced by a wide range of factors, such as the state
of the cell, experimental conditions and variants in the sequence of regulatory regions. To …
of the cell, experimental conditions and variants in the sequence of regulatory regions. To …
New insights into the genetic control of gene expression using a Bayesian multi-tissue approach
The majority of expression quantitative trait locus (eQTL) studies have been carried out in
single tissues or cell types, using methods that ignore information shared across tissues …
single tissues or cell types, using methods that ignore information shared across tissues …
An integrated hierarchical Bayesian model for multivariate eQTL mapping
MP Scott-Boyer, GC Imholte, A Tayeb… - … in genetics and …, 2012 - degruyter.com
Recently, expression quantitative loci (eQTL) mapping studies, where expression levels of
thousands of genes are viewed as quantitative traits, have been used to provide greater …
thousands of genes are viewed as quantitative traits, have been used to provide greater …
Effectively identifying regulatory hotspots while capturing expression heterogeneity in gene expression studies
Expression quantitative trait loci (eQTL) mapping is a tool that can systematically identify
genetic variation affecting gene expression. eQTL mapping studies have shown that certain …
genetic variation affecting gene expression. eQTL mapping studies have shown that certain …
Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots
In genomewide mapping of expression quantitative trait loci (eQTL), it is widely believed that
thousands of genes are trans-regulated by a small number of genomic regions called …
thousands of genes are trans-regulated by a small number of genomic regions called …
Constraints on eQTL fine mapping in the presence of multisite local regulation of gene expression
B Zeng, LR Lloyd-Jones, A Holloway… - G3: Genes …, 2017 - academic.oup.com
Expression quantitative trait locus (eQTL) detection has emerged as an important tool for
unraveling of the relationship between genetic risk factors and disease or clinical …
unraveling of the relationship between genetic risk factors and disease or clinical …
[HTML][HTML] Accommodating pathway information in expression quantitative trait locus analysis
J Wessel, MA Zapala, NJ Schork - Genomics, 2007 - Elsevier
The availability of high-throughput genotyping technologies and microarray assays has
allowed researchers to consider pursuing investigations whose ultimate goal is the …
allowed researchers to consider pursuing investigations whose ultimate goal is the …
A model selection approach for expression quantitative trait loci (eQTL) mapping
P Wang, JA Dawson, MP Keller, BS Yandell… - Genetics, 2011 - academic.oup.com
Identifying the genetic basis of complex traits remains an important and challenging problem
with the potential to affect a broad range of biological endeavors. A number of statistical …
with the potential to affect a broad range of biological endeavors. A number of statistical …
Genetical genomics: use all data
Background Genetical genomics is a very powerful tool to elucidate the basis of complex
traits and disease susceptibility. Despite its relevance, however, statistical modeling of …
traits and disease susceptibility. Despite its relevance, however, statistical modeling of …