Blueprinting expandable nanomaterials with standardized protein building blocks

TF Huddy, Y Hsia, RD Kibler, J Xu, N Bethel… - bioRxiv, 2023 - biorxiv.org
A wooden house frame consists of many different lumber pieces, but because of the
regularity of these building blocks, the structure can be designed using straightforward …

Blueprinting extendable nanomaterials with standardized protein blocks

TF Huddy, Y Hsia, RD Kibler, J Xu, N Bethel… - Nature, 2024 - nature.com
A wooden house frame consists of many different lumber pieces, but because of the
regularity of these building blocks, the structure can be designed using straightforward …

De Novo Design of Polyhedral Protein Assemblies: Before and After the AI Revolution

BB Mallik, J Stanislaw, TM Alawathurage… - …, 2023 - Wiley Online Library
Self‐assembling polyhedral protein biomaterials have gained attention as engineering
targets owing to their naturally evolved sophisticated functions, ranging from protecting …

Geometric lessons and design strategies for nanoscale protein cages

J Laniado, KA Cannon, JE Miller, MR Sawaya… - ACS …, 2021 - ACS Publications
Protein molecules bring a rich functionality to the field of designed nanoscale architectures.
High-symmetry protein cages are rapidly finding diverse applications in biomedicine …

Rationally engineering natural protein assemblies in nanobiotechnology

S Howorka - Current opinion in biotechnology, 2011 - Elsevier
Multimeric protein assemblies are essential components in viruses, bacteria, eukaryotic
cells, and organisms where they act as cytoskeletal scaffold, storage containers, or for …

Structure-based design of novel polyhedral protein nanomaterials

A Khmelinskaia, A Wargacki, NP King - Current opinion in microbiology, 2021 - Elsevier
Organizing matter at the atomic scale is a central goal of nanotechnology. Bottom-up
approaches, in which molecular building blocks are programmed to assemble via …

Geometric principles for designing highly symmetric self-assembling protein nanomaterials

TO Yeates - Annual review of biophysics, 2017 - annualreviews.org
Emerging protein design strategies are enabling the creation of diverse, self-assembling
supramolecular structures with precision on the atomic scale. The design possibilities …

Protein design of two-component tubular assemblies like cytoskeletons

M Noji, Y Sugita, Y Yamazaki, M Miyazaki, Y Suzuki - bioRxiv, 2024 - biorxiv.org
Recent advances in protein design have ushered in an era of constructing intricate higher-
order structures. Despite this progress, orchestrating the assembly of diverse protein units …

Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks

Y Hsia, R Mout, W Sheffler, NI Edman, I Vulovic… - bioRxiv, 2020 - biorxiv.org
A goal of de novo protein design is to develop a systematic and robust approach to
generating complex nanomaterials from stable building blocks. Due to their structural …

Design of multi-scale protein complexes by hierarchical building block fusion

Y Hsia, R Mout, W Sheffler, NI Edman, I Vulovic… - Nature …, 2021 - nature.com
A systematic and robust approach to generating complex protein nanomaterials would have
broad utility. We develop a hierarchical approach to designing multi-component protein …