Reversible protein phosphorylation is the main mechanism of signal transduction that
enables cells to rapidly respond to environmental changes by controlling the functional …

Protein phosphorylation/dephosphorylation has long been considered a recent addition to
Nature's regulatory arsenal. Early studies indicated that this molecular regulatory …

In the quest for the origin and evolution of protein phosphorylation, the major regulatory post-
translational modification in eukaryotes, the members of archaea, the “third domain of life” …

The third domain of life, the Archaea (formerly Archaebacteria), is populated by a
physiologically diverse set of microorganisms, many of which reside at the ecological …

Protein modifications not only affect protein homeostasis but can also establish new cellular
protein functions and are important components of complex cellular signal sensing and …

In this study, the in vitro and in vivo functions of the only two identified protein phosphatases,
Saci-PTP and Saci-PP2A, in the crenarchaeal model organism Sulfolobus acidocaldarius …

Protein phosphorylation plays an important role in cell signaling. However, in the Archaea,
little is known about which proteins are phosphorylated and which kinases are involved. In …

Phosphorylation events modify bacterial and archaeal proteomes, imparting cells with rapid
and reversible responses to specific environmental stimuli or niches. Phosphorylated …

Inspection of the genomes for the bacteria Bacillus subtilis 168, Borrelia burgdorferi B31,
Escherichia coli K-12, Haemophilus influenzae KW20, Helicobacter pylori 26695 …

For many years, the regulation of protein structure and function by phosphorylation and
dephosphorylation was considered a relatively recent invention that arose independently in …