Baicalin ameliorates cognitive impairment and protects microglia from LPS‐induced neuroinflammation via the SIRT1/HMGB1 pathway

Y Li, T Liu, Y Li, D Han, J Hong, N Yang… - Oxidative medicine …, 2020 - Wiley Online Library
Systemic inflammation often induces neuroinflammation and disrupts neural functions,
ultimately causing cognitive impairment. Furthermore, neuronal inflammation is the key …

Baicalin mitigates cognitive impairment and protects neurons from microglia‐mediated neuroinflammation via suppressing NLRP 3 inflammasomes and TLR 4/NF‐κB …

X Jin, MY Liu, DF Zhang, X Zhong, K Du… - CNS Neuroscience …, 2019 - Wiley Online Library
Aims Baicalin (BAI), a flavonoid compound isolated from the root of Scutellaria baicalensis
Georgi, has been established to have potent anti‐inflammation and neuroprotective …

Baicalin Mitigates the Neuroinflammation through the TLR4/MyD88/NF‐κB and MAPK Pathways in LPS‐Stimulated BV‐2 Microglia

B Li, M Wang, S Chen, M Li, J Zeng… - BioMed Research …, 2022 - Wiley Online Library
Baicalin (BA) is a major flavone from Scutellaria baicalensis Georgi and has showed
significant curative effects in Parkinson's and Alzheimer's diseases. In the present study, we …

Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway

J Gao, X Zhang, G Shu, N Chen, J Zhang… - Acta Pharmacologica …, 2022 - nature.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with cognitive
impairment that currently is uncurable. Previous study shows that trilobatin (TLB), a naturally …

Baicalein ameliorates ischemic brain damage through suppressing proinflammatory microglia polarization via inhibiting the TLR4/NF-κB and STAT1 pathway

Y Ran, S Qie, F Gao, Z Ding, S Yang, G Tian, Z Liu, J Xi - Brain research, 2021 - Elsevier
Microglial polarization mediated neuroinflammation plays an important role in the
pathological process of stroke. The aim of this study is to determine whether baicalein …

Baicalein exerts therapeutic effects against endotoxin-induced depression-like behavior in mice by decreasing inflammatory cytokines and increasing brain-derived …

HT Liu, YN Lin, MC Tsai, YC Wu, MC Lee - Antioxidants, 2022 - mdpi.com
Inflammation plays an important role in the pathophysiology of depression. This study aims
to elucidate the antidepressant effect of baicalein, an anti-inflammatory component of a …

Baicalin exerts neuroprotective effects via inhibiting activation of GSK3β/NF-κB/NLRP3 signal pathway in a rat model of depression

MJ Zeng, LP Zhou, YQ Li, F Zhao, ZY Shang… - International …, 2018 - Elsevier
Chronic stress can provoke depressive-like behaviors through activation of inflammation
and apoptosis, leading to a reduction of neurons. Antidepressant therapy may contribute to …

Bakuchiol attenuates oxidative stress and neuron damage by regulating Trx1/TXNIP and the phosphorylation of AMPK after subarachnoid hemorrhage in mice

H Liu, W Guo, H Guo, L Zhao, L Yue, X Li… - Frontiers in …, 2020 - frontiersin.org
Subarachnoid hemorrhage (SAH) is a fatal cerebrovascular condition with complex
pathophysiology that reduces brain perfusion and causes cerebral functional impairments …

Breviscapine alleviates cognitive impairments induced by transient cerebral ischemia/reperfusion through its anti-inflammatory and anti-oxidant properties in a rat …

Y Li, S Li, D Li - ACS Chemical Neuroscience, 2020 - ACS Publications
Cerebral ischemia/reperfusion (I/R)-induced injury is a common phenomenon of stroke, and
the effective treatment for I/R-induced brain tissue damage is limited. Breviscapine has been …

[HTML][HTML] Investigating neuroprotective roles of Bacopa monnieri extracts: Mechanistic insights and therapeutic implications

U Fatima, S Roy, S Ahmad, LA Al-Keridis… - Biomedicine & …, 2022 - Elsevier
Bacopa monnieri (Brahmi) is a well-known perennial, creeping herb of the Indian Ayurveda
system; it contains numerous bioactive phytoconstituents implicated in the therapeutic …