The RNA binding protein Human antigen R (HuR) interacts with specific AU-rich domains in
target mRNAs and is highly expressed in many cell types, including cardiomyocytes …

RNA binding proteins represent an emerging class of proteins with a role in cardiac
dysfunction. We show that activation of the RNA binding protein human antigen R (HuR) is …

Objective: HuR (human antigen R)—an RNA-binding protein—is involved in regulating
mRNA stability by binding adenylate-uridylate–rich elements. This study explores the role of …

The ubiquitous mRNA binding protein human antigen R (HuR) participates in the post-
transcriptional regulation of many AU-rich element (ARE)-bearing mRNAs. Previously, by …

Myocardial hypertrophy is frequently associated with poor clinical outcomes including the
development of cardiac systolic and diastolic dysfunction and ultimately heart failure. To …

In dividing cells, the RNA-binding protein HuR associates with and stabilizes labile mRNAs
encoding proliferative proteins, events that are linked to the increased cytoplasmic presence …

Background: Pyrroloquinoline quinone (PQQ) has been reported to exhibit cardioprotective
and antioxidant activities. Accordingly, this study was developed to explore the effects of …

Objective Mice deficient for the AP-1 transcription factor JunD, the only Jun protein
constitutively expressed and clearly detectable in the mammalian heart, develop enhanced …

Cardiac fibrosis is one of the key structural changes of the hypertrophied left ventricle in
hypertensive heart disease. Increased angiotensin II was found to be important in the …

ABSTRACT c-Jun N-terminal protein kinase (JNK) and p38, two distinct members of the
mitogen-activated protein (MAP) kinase family, regulate gene expression in response to …