A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis

M Grewe, CAFM Bruijnzeel-Koomen, E Schöpf… - Immunology today, 1998 - cell.com
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intensely
pruritic subacute and chronic eczematous plaques, the pathogenesis of which appears to …

[HTML][HTML] “Outside-to-inside”(and now back to “outside”) pathogenic mechanisms in atopic dermatitis

PM Elias, M Steinhoff - Journal of Investigative Dermatology, 2008 - Elsevier
The pathogenesis of atopic dermatitis (AD) has been attributed largely to abnormalities in
the adaptive immune system, with key roles played by T-helper 1 (Th1)/Th2 cell …

Cellular and immunologic mechanisms in atopic dermatitis

DYM Leung, NA Soter - Journal of the American Academy of Dermatology, 2001 - Elsevier
Atopic dermatitis is a chronic inflammatory skin disease that is frequently associated with
respiratory allergies. Atopic dermatitis develops as a result of a complex interrelationship of …

More than skin deep: the systemic nature of atopic dermatitis

C Oliveira, T Torres - European journal of dermatology, 2019 - Springer
Atopic dermatitis is a worldwide prevalent chronic inflammatory skin disease. Although
primarily recognized as a disease of children, there is increasing evidence suggesting that it …

[HTML][HTML] The role of leukocytes, keratinocytes, and allergen-specific IgE in the development of atopic dermatitis

T Werfel - Journal of Investigative Dermatology, 2009 - Elsevier
This review provides an overview of the inflammatory mechanisms and immunological
aspects specific to atopic dermatitis. The review discusses publications on the roles of …

Cellular and molecular mechanisms in atopic dermatitis

MK Oyoshi, R He, L Kumar, J Yoon, RS Geha - Advances in immunology, 2009 - Elsevier
Atopic dermatitis (AD) is a pruritic inflammatory skin disease associated with a personal or
family history of allergy. The prevalence of AD is on the rise and estimated at∼ 17% in the …

Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes

I Nomura, E Goleva, MD Howell, QA Hamid… - The Journal of …, 2003 - journals.aai.org
Atopic dermatitis (AD) and psoriasis are the two most common chronic skin diseases.
However patients with AD, but not psoriasis, suffer from frequent skin infections. To …

Severe atopic dermatitis is characterized by selective expansion of circulating TH2/TC2 and TH22/TC22, but not TH17/TC17, cells within the skin-homing T-cell …

T Czarnowicki, J Gonzalez, A Shemer… - Journal of Allergy and …, 2015 - Elsevier
Background Past studies of blood T-cell phenotyping in patients with atopic dermatitis (AD)
have provided controversial results and were mostly performed before the identification of …

Immune dysregulation in atopic dermatitis

PY Ong, DMY Leung - Current allergy and asthma reports, 2006 - Springer
Atopic dermatitis is a chronic inflammatory skin disease that causes significant morbidity in
affected individuals. It is characterized by dysregulated immune responses that consist of an …

The role of cytokines/chemokines in the pathogenesis of atopic dermatitis

K Yamanaka, H Mizutani - Pathogenesis and Management of Atopic …, 2011 - karger.com
Atopic dermatitis (AD) is the most common and relapsing allergic disease of the skin. AD is
characterized by a predominant expression of Th2-type cytokines associated with increased …