This review describes available methods for the diastereoselective and asymmetric
synthesis of quaternary prolines. The focus is on the preparation of α‐functionalized prolines …

Enantioselective synthesis of 3-substituted prolines was achieved starting from commercially
available 3-hydroxy-(S)-2-proline. Palladium-mediated couplings were used to introduce a …

An efficient method for the stereoselective synthesis of cis-3-substituted prolines: conformationally
constrained α-amino acids - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals …

Enantiopure quaternary prolines have been prepared by stereoselective rearrangement of N‐
(arylsulfonyl) proline tert‐butyl esters under basic conditions (see scheme), without any …

Ring formation involving a 5-exo trig cyclization between a zinc enolate and a non activated
double bond led to cis diastereoisomer of 3-substituted prolines. This cyclization was …

The synthesis of optically active cis 3-aryl proline derivatives was achieved in a five-step
sequence involving an enantioselective aza-Claisen rearrangement as the key step. Initially …

N-Tritylprolinal: An Efficient Building Block for the Stereoselective Synthesis of Proline-Derived
Amino Alcohols | The Journal of Organic Chemistry ACS ACS Publications C&EN CAS Find …

Starting from aspartic acid an efficient synthesis of enantiomerically pure β-proline and
homo-β-proline is described. The key step of the synthesis includes formation of the 1, 4 …

The asymmetric synthesis of substituted pyrrolidines has been accomplished using a novel
organocatalytic cyclization reaction promoted by a Cinchona alkaloid based primary amine …

Non-proteinogenic prolines have been acknowledged as an important pool for the synthesis
of conformationally rigid bioactive peptides, angiotensin converting enzyme inhibitors and …