Significance: In recent decades, male fertility has been severely reduced worldwide. The
causes underlying this decline are multifactorial, and include, among others, genetic …

In recent decades, male fertility has been severely reduced worldwide. The causes
underlying this decline are multifactorial and include, among others, genetic alterations …

Reactive oxygen species (ROS) are free radicals derived from oxygen during normal cellular
metabolism. ROS play a crucial role in the physiological processes and signalling pathways …

Reactive oxygen species (ROS) play a critical role in defining the functional competence of
human spermatozoa. When generated in moderate amounts, ROS promote sperm …

Oxidative energy production is inevitably associated with the generation of reactive oxygen
species (ROS), excessive concentrations of which can lead to cellular pathology. A free …

Reactive oxygen species (ROS) can be generated in mammalian cells via both enzymatic
and non-enzymatic mechanisms. In sperm cells, while ROS may function as signalling …

The production of reactive oxygen species (ROS) is a normal physiological event in the male
germ line. ROS are a double-edged sword, despite its role as key signaling molecules in …

Human infertility affects~ 15% of couples worldwide, and it is now recognized that in half of
these cases, the causes of infertility can be traced to men [1, 2]. The spermatozoon is a …

Spermatozoa are physiologically exposed to reactive oxygen species (ROS) that play a
pivotal role on several sperm functions through activation of different intracellular …

Male infertility is linked to several environmental and mutagenic factors. Most of these
factors, ie, lifestyle, radiations, and chemical contaminations, work on the fundamental …