[HTML][HTML] Roles of systemic inflammatory and metabolic responses in the pathophysiology of acute-on-chronic liver failure

J Clària, V Arroyo, R Moreau - JHEP Reports, 2023 - Elsevier
Acute-on-chronic liver failure (ACLF) is the most severe form of acutely decompensated
cirrhosis and is characterised by the presence of one or more organ failures, intense …

[HTML][HTML] The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis

V Arroyo, P Angeli, R Moreau, R Jalan, J Clària… - Journal of …, 2021 - Elsevier
Acute decompensation (AD) of cirrhosis is defined by the development of ascites, hepatic
encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to …

Mechanisms of immunity in acutely decompensated cirrhosis and acute‐on‐chronic liver failure

C Engelmann, IW Zhang, J Clària - Liver International, 2023 - Wiley Online Library
The identification of systemic inflammation (SI) as a central player in the orchestration of
acute‐on‐chronic liver failure (ACLF) has opened new avenues for the understanding of the …

The acute-on-chronic liver failure syndrome, or when the innate immune system goes astray

J Clària, V Arroyo, R Moreau - The Journal of Immunology, 2016 - journals.aai.org
The acute-on-chronic liver failure (ACLF) syndrome is characterized by acute
decompensation of cirrhosis, organ failure, and high 28-d mortality. ACLF displays key …

Leukocytes, systemic inflammation and immunopathology in acute-on-chronic liver failure

M Casulleras, IW Zhang, C López-Vicario, J Clària - Cells, 2020 - mdpi.com
Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with
cirrhosis and is characterized by acute decompensation, organ failure (s) and high short …

Dysfunctional immune response in acute-on-chronic liver failure: it takes two to tango

R Martin-Mateos, M Alvarez-Mon, A Albillos - Frontiers in immunology, 2019 - frontiersin.org
Acute-on-chronic liver failure (ACLF) is characterized by the acute decompensation of
cirrhosis associated with organ failure and high short-term mortality. The key event in the …

Acute on chronic liver failure and immune dysfunction: a mimic of sepsis

MK Hensley, JC Deng - Seminars in Respiratory and Critical …, 2018 - thieme-connect.com
Both the adaptive and innate arms of immunity are altered in patients with cirrhosis, which
have both prognostic and clinical implications. Acute on chronic liver failure (ACLF), defined …

Bench-to-beside review: acute-on-chronic liver failure-linking the gut, liver and systemic circulation

L Verbeke, F Nevens, W Laleman - Critical Care, 2011 - Springer
The concept of acute-on-chronic liver failure (ACLF) was introduced recently to describe a
subset of patients with chronic liver disease presenting with profound deterioration of liver …

Immunodysfunction in acute-on-chronic liver failure

CM Lange, R Moreau - Visceral Medicine, 2018 - karger.com
Background: Increasing evidence reveals a close and reciprocal link between acute-on-
chronic liver failure (ACLF) and immunodysfunction. Methods: A literature search in PubMed …

[HTML][HTML] Role of inflammation and infection in the pathogenesis of human acute liver failure: clinical implications for monitoring and therapy

MC Donnelly, PC Hayes… - World Journal of …, 2016 - ncbi.nlm.nih.gov
Acute liver failure is a rare and devastating clinical condition. At present, emergency liver
transplantation is the only life-saving therapy in advanced cases, yet the feasibility of …