ICI 182,780 attenuates selective upregulation of uterine artery cystathionine β-synthase expression in rat pregnancy

J Bai, Y Li, G Yan, J Zhou, AG Salmeron… - International Journal of …, 2023 - mdpi.com
Endogenous hydrogen sulfide (H2S) produced by cystathionine β-synthase (CBS) and
cystathionine-γ lyase (CSE) has emerged as a novel uterine vasodilator contributing to …

Augmented H2S production via cystathionine-beta-synthase upregulation plays a role in pregnancy-associated uterine vasodilation

L Sheibani, TJ Lechuga, H Zhang… - Biology of …, 2017 - academic.oup.com
Endogenous hydrogen sulfide (H2S) synthesized via metabolizing L-cysteine by
cystathionine-beta-synthase (CBS) and cystathionine-gamma-lyase (CSE) is a potent …

E2β stimulates ovine uterine artery endothelial cell H2S production in vitro by estrogen receptor-dependent upregulation of cystathionine β-synthase and …

TJ Lechuga, Q Qi, T Kim, RR Magness… - Biology of …, 2019 - academic.oup.com
Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic second
messenger synthesized from L-cysteine by cystathionine β-synthase (CBS) and …

ERα/ERβ-directed CBS transcription mediates E2β-stimulated huaec H2S production

J Bai, TJ Lechuga, J Makhoul, H Yan… - Journal of …, 2023 - jme.bioscientifica.com
Elevated endogenous estrogens stimulate human uterine artery endothelial cell (hUAEC)
hydrogen sulfide (H 2 S) production by selectively upregulating the expression of H 2 S …

Estrogen replacement therapy in ovariectomized nonpregnant ewes stimulates uterine artery hydrogen sulfide biosynthesis by selectively up-regulating cystathionine …

TJ Lechuga, H Zhang, L Sheibani, M Karim, J Jia… - …, 2015 - academic.oup.com
Estrogens dramatically dilate numerous vascular beds with the greatest response in the
uterus. Endogenous hydrogen sulfide (H2S) is a potent vasodilator and proangiogenic …

Ovine uterine artery hydrogen sulfide biosynthesis in vivo: effects of ovarian cycle and pregnancy

TJ Lechuga, Q Qi, RR Magness… - Biology of …, 2019 - academic.oup.com
Uterine vasodilation dramatically increases during the follicular phase of the estrous cycle
and pregnancy, which are estrogen-dominant physiological states. Uterine vasodilation is …

Enhanced Sp1/YY1 Expression Directs CBS Transcription to Mediate VEGF-Stimulated Pregnancy-Dependent H2S Production in Human Uterine Artery Endothelial …

J Bai, D Chen - Hypertension, 2021 - Am Heart Assoc
Pregnancy and VEGF (vascular endothelial growth factor) stimulate uterine artery
endothelial cell (UAEC) hydrogen sulfide production via selectively upregulating CBS …

Estradiol‐17β stimulates H2S biosynthesis by ER‐dependent CBS and CSE transcription in uterine artery smooth muscle cells in vitro

TJ Lechuga, AK Bilg, BA Patel… - Journal of cellular …, 2019 - Wiley Online Library
Endogenous hydrogen sulfide (H2S), synthesized by cystathionine β‐synthase (CBS) and
cystathionine γ‐lyase (CSE), is a potent vasodilator that can be stimulated by estradiol‐17β …

Enhanced Stromal Cell CBS-H2S Production Promotes Estrogen-Stimulated Human Endometrial Angiogenesis

QR Qi, TJ Lechuga, B Patel, NA Nguyen… - …, 2020 - academic.oup.com
Angiogenesis is a physiological process for endometrial regeneration in the menstrual cycle
and remodeling during pregnancy. Endogenous hydrogen sulfide (H2S), produced by …

[HTML][HTML] Cystathionine γ-lyase promotes estrogen-stimulated uterine artery blood flow via glutathione homeostasis

R Bok, DD Guerra, RA Lorca, SA Wennersten… - Redox Biology, 2021 - Elsevier
Abstract During pregnancy, estrogen (E 2) stimulates uterine artery blood flow (UBF) by
enhancing nitric oxide (NO)-dependent vasodilation. Cystathionine γ-lyase (CSE) promotes …