Introduction: Beta-lactam antibiotics are one of the most common causes of antibiotics-
related severe cutaneous adverse reactions (SCARs) including Stevens–Johnson syndrome …

Genetic risk factors could cause cutaneous adverse drug reactions (cADR s) in patients after
treatment with clarithromycin. This study explored the association of HLA class I genes with …

Clindamycin causes cutaneous adverse drug reactions (cADRs), sometimes with the
mechanisms of pathogenicity or risk factors unknown. This study aims to assess whether …

Human leukocyte antigen (HLA) encoded by the HLA gene is an important modulator for
immune responses and drug hypersensitivity reactions as well. Genetic polymorphisms of …

Phenytoin (PHT) is a common cause of severe cutaneous adverse reactions (SCARs),
including Stevens–Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug …

Background Co-trimoxazole is a sulfonamide-containing antibiotic that is effective in the
treatment of several infections and for prophylaxis of Pneumocystis jiroveci pneumonia. This …

Adverse drug reactions can cause considerable discomfort. They can be life-threatening in
severe cases, requiring or prolonging hospitalization, impeding proper treatment, and …

Severe cutaneous adverse drug reaction (SCAR) is considered to be a multifactorial drug
side effect. This study was designed to investigate the epidemiology and human leukocyte …

Introduction: Pharmacogenomics has great potential in reducing drug-induced severe
cutaneous adverse drug reactions (SCARs). Pharmacogenomic studies have revealed an …

T‐cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal
reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or …