Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration
KK Pandey, S Sinha, DP Grandgenett - Journal of virology, 2007 - Am Soc Microbiol
Human transcriptional coactivator p75/lens epithelium-derived growth factor (LEDGF) binds
human immunodeficiency virus type 1 (HIV-1) integrase (IN). We studied the effects of …
human immunodeficiency virus type 1 (HIV-1) integrase (IN). We studied the effects of …
[HTML][HTML] LEDGF/p75 interferes with the formation of synaptic nucleoprotein complexes that catalyze full-site HIV-1 DNA integration in vitro: implications for the …
NK Raghavendra, A Engelman - Virology, 2007 - Elsevier
An integrase dimer can process and integrate a single HIV-1 DNA end in vitro, whereas a
tetramer is required to integrate two ends. LEDGF/p75 can potently stimulate integrase …
tetramer is required to integrate two ends. LEDGF/p75 can potently stimulate integrase …
In vitro DNA tethering of HIV-1 integrase by the transcriptional coactivator LEDGF/p75
M McNeely, J Hendrix, K Busschots, E Boons… - Journal of molecular …, 2011 - Elsevier
Although LEDGF/p75 is believed to act as a cellular cofactor of lentiviral integration by
tethering integrase (IN) to chromatin, there is no good in vitro model to analyze this …
tethering integrase (IN) to chromatin, there is no good in vitro model to analyze this …
LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration
MC Shun, NK Raghavendra… - Genes & …, 2007 - genesdev.cshlp.org
LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their
enzymatic activities and chromosomal association. A novel genetic knockout model was …
enzymatic activities and chromosomal association. A novel genetic knockout model was …
Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75
M Llano, M Vanegas, N Hutchins, D Thompson… - Journal of molecular …, 2006 - Elsevier
Depletion of the transcriptional co-activator LEDGF/p75 by RNA interference alters the
genome-wide pattern of HIV-1 integration, reducing integration into active genes, reducing …
genome-wide pattern of HIV-1 integration, reducing integration into active genes, reducing …
LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity
AM Meehan, DT Saenz, J Morrison, C Hu… - Journal of …, 2011 - Am Soc Microbiol
Target cell overexpression of the integrase binding domain (IBD) of LEDGF/p75 (LEDGF)
inhibits HIV-1 replication. The mechanism and protein structure requirements for this …
inhibits HIV-1 replication. The mechanism and protein structure requirements for this …
Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus
L Vandekerckhove, F Christ, B Van Maele… - Journal of …, 2006 - Am Soc Microbiol
After identifying the interaction between the transcriptional coactivator lens epithelium-
derived growth factor (LEDGF/p75) and the human immunodeficiency virus type 1 (HIV-1) …
derived growth factor (LEDGF/p75) and the human immunodeficiency virus type 1 (HIV-1) …
[HTML][HTML] Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex
M Tsiang, GS Jones, M Hung, S Mukund, B Han… - Journal of Biological …, 2009 - ASBMB
The interaction between lens epithelium-derived growth factor/transcriptional co-activator
p75 (LEDGF) and human immunodeficiency virus type 1 (HIV-1) integrase (IN) is essential …
p75 (LEDGF) and human immunodeficiency virus type 1 (HIV-1) integrase (IN) is essential …
[HTML][HTML] The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication
A Engelman, P Cherepanov - PLoS pathogens, 2008 - journals.plos.org
Retroviral replication proceeds through a stable proviral DNA intermediate, and numerous
host cell factors have been implicated in its formation. In particular, recent results have …
host cell factors have been implicated in its formation. In particular, recent results have …
LEDGF/p75 interacts with divergent lentiviral integrases and modulates their enzymatic activity in vitro
P Cherepanov - Nucleic acids research, 2007 - academic.oup.com
Transcriptional co-activator LEDGF/p75 is the major cellular interactor of HIV-1 integrase
(IN), critical to efficient viral replication. In this work, a series of INs from the Betaretrovirus …
(IN), critical to efficient viral replication. In this work, a series of INs from the Betaretrovirus …