Lateral hypothalamus (LH) orexin neuron signaling has been implicated in the motivation to
seek and take drugs of abuse. The number of LH orexin neurons has been shown to be …

Orexins (also called hypocretins) have been shown to be importantly involved in reward and
addiction, but little is known about the circuitry that regulates orexin neuronal activity during …

Background The orexin (hypocretin) system is important for reward-driven motivation but has
not been implicated in the expression of a multiphenotype addicted state. Methods Rats …

Orexins (synonymous with hypocretins) are recently discovered neuropeptides made
exclusively in hypothalamus. Behavioral, anatomical, and neurophysiological studies show …

Orexins (also known as hypocretins) are recently discovered neuropeptides made
exclusively in hypothalamic neurons that have been shown to be important in …

Despite a history of more than a century of intense research in drug addiction, with currently
available medication and behavioral therapy, the rate of relapse to drug use is 40–60 …

Abstract Hypothalamic orexin/hypocretin (Orx/Hcrt) neurons are thought to mediate both
food‐reinforced behaviors and behavior motivated by drugs of abuse. However, the relative …

The orexin/hypocretin system is involved in multiple cocaine addiction processes that
involve drug‐associated environmental cues, including cue‐induced reinstatement of …

Drug-associated sensory cues increase motivation for drug and the orexin system is
importantly involved in this stimulus-enhanced motivation. Ventral tegmental area (VTA) is a …

Preclinical research has sought to understand the role of the orexin system in cocaine
addiction given the connection between orexin producing cells in the lateral hypothalamus …