miR-199a-3p promotes gastric cancer progression by promoting its stemness potential via DDR2 mediation
L Ren, Q Ren, J Wang, Y He, H Deng, X Wang, C Liu - Cellular Signalling, 2023 - Elsevier
Background Peritoneal metastasis (PM) is an independent prognostic factor in gastric
cancer (GC), however, the underlying mechanisms of PM occurrence remain unclear …
cancer (GC), however, the underlying mechanisms of PM occurrence remain unclear …
[HTML][HTML] Integrated molecular profiling of human gastric cancer identifies DDR2 as a potential regulator of peritoneal dissemination
Peritoneal dissemination is the most frequent, incurable metastasis occurring in patients with
advanced gastric cancer (GC). However, molecular mechanisms driving peritoneal …
advanced gastric cancer (GC). However, molecular mechanisms driving peritoneal …
DDR2 induces gastric cancer cell activities via activating mTORC2 signaling and is associated with clinicopathological characteristics of gastric cancer
YG Wang, L Xu, RR Jia, Q Wu, T Wang, J Wei… - Digestive diseases and …, 2016 - Springer
Abstract Background/Aim Epithelial–mesenchymal transition (EMT) plays a role in cancer
progression. Previous studies have suggested that discoidin domain receptor 2 (DDR2) is …
progression. Previous studies have suggested that discoidin domain receptor 2 (DDR2) is …
DDR1 enhances invasion and metastasis of gastric cancer via epithelial-mesenchymal transition
R Xie, X Wang, G Qi, Z Wu, R Wei, P Li, D Zhang - Tumor Biology, 2016 - Springer
In this study, we investigated the effects of DDR1 on the invasion and metastasis in gastric
cancer (GC) via epithelial-mesenchymal transition (EMT). Immunohistochemistry analysis …
cancer (GC) via epithelial-mesenchymal transition (EMT). Immunohistochemistry analysis …
DDR2 expression is associated with a high frequency of peritoneal dissemination and poor prognosis in colorectal cancer
S Sasaki, M Ueda, T Iguchi, M Kaneko… - Anticancer …, 2017 - ar.iiarjournals.org
Background: We previously identified discoidin-domain receptor 2 (DDR2) as a promising
driver gene of peritoneal dissemination (PD) in gastric cancer. In the present study we …
driver gene of peritoneal dissemination (PD) in gastric cancer. In the present study we …
microRNA‐95 knockdown inhibits epithelial–mesenchymal transition and cancer stem cell phenotype in gastric cancer cells through MAPK pathway by upregulating …
M Du, Y Zhuang, P Tan, Z Yu, X Zhang… - Journal of Cellular …, 2020 - Wiley Online Library
This study investigated the role of microRNA‐95 (miR‐95) in gastric cancer (GC) and to
elucidate the underlying mechanism. Initially, bioinformatic prediction was used to predict …
elucidate the underlying mechanism. Initially, bioinformatic prediction was used to predict …
MiR-199a-5p loss up-regulated DDR1 aggravated colorectal cancer by activating epithelial-to-mesenchymal transition related signaling
Y Hu, J Liu, B Jiang, J Chen, Z Fu, F Bai, J Jiang… - Digestive diseases and …, 2014 - Springer
Background Discoidin domain receptors1 (DDR1) is associated with tumor progression, and
its dysregulated expression has been observed in many cancers. Aim We aim to explore …
its dysregulated expression has been observed in many cancers. Aim We aim to explore …
[HTML][HTML] miR-155-5p inhibition promotes the transition of bone marrow mesenchymal stem cells to gastric cancer tissue derived MSC-like cells via NF-κB p65 …
M Zhu, M Wang, F Yang, Y Tian, J Cai, H Yang, H Fu… - Oncotarget, 2016 - ncbi.nlm.nih.gov
Gastric cancer tissue-derived MSC-like cells (GC-MSC) share similar characteristics to bone
marrow MSC (BM-MSC); however, the phenotypical and functional differences and the …
marrow MSC (BM-MSC); however, the phenotypical and functional differences and the …
Inhibition of discoidin domain receptor 1 prevents stroma-induced peritoneal metastasis in gastric carcinoma
H Jin, IH Ham, HJ Oh, CA Bae, D Lee, YB Kim… - Molecular Cancer …, 2018 - AACR
Abstract Discoidin domain receptor 1 (DDR1) is activated by fibrillar (triple-helical) collagens
and collagen IV, which are major components of tumor stroma; thus, DDR1 might be a …
and collagen IV, which are major components of tumor stroma; thus, DDR1 might be a …
miR-151a-3p-rich small extracellular vesicles derived from gastric cancer accelerate liver metastasis via initiating a hepatic stemness-enhancing niche
B Li, Y Xia, J Lv, W Wang, Z Xuan, C Chen, T Jiang… - Oncogene, 2021 - nature.com
Liver metastasis (LM) severely affects gastric cancer (GC) patients' prognosis. Small
extracellular vesicles (sEVs) play key roles in intercellular communication. Specific sEV …
extracellular vesicles (sEVs) play key roles in intercellular communication. Specific sEV …