Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis

SF Roemer, JE Parisi, VA Lennon, EE Benarroch… - Brain, 2007 - academic.oup.com
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that typically affects
optic nerves and spinal cord. Its pathogenic relationship to multiple sclerosis (MS) is …

Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis

T Misu, K Fujihara, A Kakita, H Konno, M Nakamura… - Brain, 2007 - academic.oup.com
Neuromyelitis optica (NMO) is an inflammatory and necrotizing disease clinically
characterized by selective involvement of the optic nerves and spinal cord. There has been …

[HTML][HTML] Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica

F Paul, S Jarius, O Aktas, M Bluthner, O Bauer… - PLoS …, 2007 - journals.plos.org
Background Neuromyelitis optica (NMO) is a demyelinating disease of the central nervous
system (CNS) of putative autoimmune aetiology. Early discrimination between multiple …

Antibody to aquaporin-4 in the long-term course of neuromyelitis optica

S Jarius, F Aboul-Enein, P Waters, B Kuenz, A Hauser… - Brain, 2008 - academic.oup.com
Neuromyelitis optica (NMO) is a severe inflammatory CNS disorder of putative autoimmune
aetiology, which predominantly affects the spinal cord and optic nerves. Recently, a highly …

AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance

S Jarius, B Wildemann - Nature Reviews Neurology, 2010 - nature.com
Antibodies to aquaporin-4 (also known as AQP4-Ab or NMO-IgG) are sensitive and highly
specific serum markers of autoimmune neuromyelitis optica (NMO). Second-generation …

[HTML][HTML] Neuromyelitis optica pathogenesis and aquaporin 4

DJ Graber, M Levy, D Kerr, WF Wade - Journal of neuroinflammation, 2008 - Springer
Neuromyelitis optica (NMO) is a severe, debilitating human disease that predominantly
features immunopathology in the optic nerves and the spinal cord. An IgG1 autoantibody …

Absence of aquaporin-4 expression in lesions of neuromyelitis optica but increased expression in multiple sclerosis lesions and normal-appearing white matter

C Sinclair, J Kirk, B Herron, U Fitzgerald… - Acta …, 2007 - Springer
Abstract Aquaporin-4 (AQP4) has recently been implicated in the pathogenesis of
neuromyelitis optica (NMO) where it has been identified as the first defined autoantigen …

Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2

SR Hinson, SF Roemer, CF Lucchinetti… - The Journal of …, 2008 - rupress.org
Neuromyelitis optica (NMO)-immunoglobulin G (IgG) is a clinically validated serum
biomarker that distinguishes relapsing central nervous system (CNS) inflammatory …

NMO-IgG: a specific biomarker for neuromyelitis optica

BG Weinshenker, DM Wingerchuk, SJ Pittock… - Disease …, 2006 - content.iospress.com
Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that principally targets
the optic nerves and spinal cord and often leads to severe disability and occasionally life …

Neuromyelitis optica should be classified as an astrocytopathic disease rather than a demyelinating disease

K Fujihara, T Misu, I Nakashima… - Clinical and …, 2012 - Wiley Online Library
Neuromyelitis optica (NMO) is characterized by severe optic neuritis and transverse myelitis.
The relationship of NMO to multiple sclerosis (MS) has long been debated, but NMO has …