Exhaled aldehydes as biomarkers for lung diseases: a narrative review

MA Floss, T Fink, F Maurer, T Volk, S Kreuer… - Molecules, 2022 - mdpi.com
Breath analysis provides great potential as a fast and non-invasive diagnostic tool for
several diseases. Straight-chain aliphatic aldehydes were repeatedly detected in the breath …

Lipid peroxidation produces a diverse mixture of saturated and unsaturated aldehydes in exhaled breath that can serve as biomarkers of lung cancer—a review

SR Sutaria, SS Gori, JD Morris, Z Xie, XA Fu, MH Nantz - Metabolites, 2022 - mdpi.com
The peroxidation of unsaturated fatty acids is a widely recognized metabolic process that
creates a complex mixture of volatile organic compounds including aldehydes. Elevated …

Quantification of volatile aldehydes deriving from in vitro lipid peroxidation in the breath of ventilated patients

LM Müller-Wirtz, D Kiefer, S Ruffing, T Brausch… - Molecules, 2021 - mdpi.com
Exhaled aliphatic aldehydes were proposed as non-invasive biomarkers to detect increased
lipid peroxidation in various diseases. As a prelude to clinical application of the …

Breath carbonyl levels in a human population of seven hundred participants

MM McCartney, CJ Thompson, LR Klein… - Journal of breath …, 2020 - iopscience.iop.org
Oxidative stress is associated with numerous health conditions and disorders, and
aldehydes are known biomarkers of oxidative stress that can be non-invasively measured in …

Aldehydes in exhaled breath condensate of patients with chronic obstructive pulmonary disease

M Corradi, I Rubinstein, R Andreoli… - American journal of …, 2003 - atsjournals.org
The aims of the present study were (1) to evaluate whether individual aldehydes resulting
from lipid peroxidation can be measured in exhaled breath condensate,(2) to assess the …

Identification of 2-alkenals, 4-hydroxy-2-alkenals, and 4-hydroxy-2, 6-alkadienals in exhaled breath condensate by UHPLC-HRMS and in breath by real-time HRMS

D García-Gómez, P Martínez-Lozano Sinues… - Analytical …, 2015 - ACS Publications
In recent years, breath analysis in real time has become a noninvasive alternative for the
diagnosis of diseases and for molecular fingerprinting of exhaled breath. However, the …

Investigation of C3–C10 aldehydes in the exhaled breath of healthy subjects using selected ion flow tube-mass spectrometry (SIFT-MS)

J Huang, S Kumar, GB Hanna - Journal of Breath Research, 2014 - iopscience.iop.org
Aldehydes have attracted great scientific and clinical interest as potential disease
biomarkers. We have investigated selected ion flow tube-mass spectrometry (SIFT-MS) in …

Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical …

R Andreoli, P Manini, M Corradi, A Mutti… - Rapid …, 2003 - Wiley Online Library
A method for the simultaneous determination of several classes of aldehydes in exhaled
breath condensate (EBC) was developed using liquid chromatography/atmospheric …

Breath gas aldehydes as biomarkers of lung cancer

P Fuchs, C Loeseken, JK Schubert… - International Journal of …, 2010 - Wiley Online Library
There is experimental evidence that volatile substances in human breath can reflect
presence of neoplasma. Volatile aldehydes were determined in exhaled breath of 12 lung …

Determination of aldehydes in exhaled breath of patients with lung cancer by means of on-fiber-derivatisation SPME–GC/MS

D Poli, M Goldoni, M Corradi, O Acampa… - … of Chromatography B, 2010 - Elsevier
A number of volatile organic compounds (VOCs) have been identified and used in
preliminary clinical studies of the early diagnosis of lung cancer. The aim of this study was to …