Abstract Ischemia/reperfusion (I/R) injury is a major cause of myocardial damage. Despite
continuous efforts, minimizing I/R injury still represents a great challenge in standard …

Minimizing myocardial ischemia-reperfusion injury has broad clinical implications and is a
critical mediator of cardiac surgical outcomes.“Ischemic injury” results from a restriction in …

Reperfusion therapy has resulted in significant improvement in post-myocardial infarction
morbidity and mortality in over the last 4 decades. Nonetheless, it is well recognized that …

Myocardial injury as induced by myocardial infarction results in tissue ischemia, which
critically incepts cardiomyocyte death. Endothelial cells play a crucial role in restoring …

Ischemia and reperfusion may result in injury to one or more of the cellular components of
the heart. In addition to damaging myocytes and their contractile capability, ischemia and …

Cardiovascular diseases are one of the leading causes of mortality in developed countries.
Among cardiovascular disorders, myocardial infarction remains a life-threatening problem …

Endothelial cells (EC) serve a paracrine function to enhance signaling in cardiomyocytes
(CM), and conversely, CM secrete factors that impact EC function. Understanding how EC …

Despite the progress of cardiovascular medicine, ischemia-reperfusion injury can contribute
to increased mortality and prolonged hospitalization after myocardial infarction. Ischemia …

BACKGROUND.: The consequences of ischemia-reperfusion injury on myocytes has been
studied intensely, and previous investigations of methods of myocardial protection during …

Endothelial barrier integrity is required for maintaining vascular homeostasis and fluid
balance between the circulation and surrounding tissues and for preventing the …