In epithelial tissues, the lineage relationship between normal progenitor cells and cell type
(s) of origin for cancer has been poorly understood. Here we show that a known regulator of …

The intrinsic ability to exhibit self-organizing morphogenetic properties in ex vivo culture may
represent a general property of tissue stem cells. Here we show that single luminal …

Recent lineage tracing studies support the existence of prostate luminal progenitors that
possess extensive regenerative capacity, but their identity remains unknown. We show that …

The existence of prostate stem cells (PSCs) was first postulated from the observation that
normal prostate regeneration can occur after repeated cycles of androgen deprivation and …

The prostate is a glandular epithelium composed of basal, luminal and neuroendocrine cells
that originate from the urogenital sinus during embryonic development. After birth, the …

The cell of origin for prostate cancer remains a subject of debate. Genetically engineered
mouse models have demonstrated that both basal and luminal cells can serve as cells of …

The identification of cell types of origin for cancer has important implications for tumor
stratification and personalized treatment. For prostate cancer, the cell of origin has been …

The identification of prostate stem/progenitor cells and characterization of the prostate
epithelial cell lineage hierarchy are critical for understanding prostate cancer initiation. Here …

Androgen deprivation is the cornerstone of prostate cancer treatment. It results in involution
of the normal gland to~ 90% of its original size because of the loss of luminal cells. The …

Androgen signals through androgen receptor (AR) to influence prostate development and
cancer. How stromal and epithelial AR regulate prostate homeostasis remains unclear …