Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt‐agonistic R‐
spondins (RSPOs). Intestinal, stomach and liver Lgr5+ stem cells grow in 3D cultures to form …

Pioneering studies within the last few years have allowed the in vitro expansion of tissue‐
specific adult stem cells from a variety of endoderm‐derived organs, including the stomach …

Since the discovery of LGR5 as a marker of intestinal stem cells, the field has developed
explosively and led to many new avenues of research. The inner workings of the intestinal …

Recent examples have highlighted how stem cells have the capability to initiate
morphogenesis in vitro; that is, to generate complex structures in culture that closely parallel …

The clonal isolation of putative adult pancreatic precursors has been an elusive goal of
researchers seeking to develop cell replacement strategies for diabetes. We report the …

Wnt signalling stimulated by binding of R-spondin (Rspo) to Lgr-family members is crucial
for gastrointestinal stem cell renewal. Infection of the stomach with Helicobacter pylori …

The Wnt/β-catenin signaling pathbway controls many important biological processes. R-
Spondin (RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/β …

Abstract The Wnt target gene Lgr5 (leucine-rich-repeat-containing G-protein-coupled
receptor 5) marks actively dividing stem cells in Wnt-driven, self-renewing tissues such as …

The canonical Wnt/β-catenin signalling pathway governs diverse developmental,
homeostatic and pathological processes. Palmitoylated Wnt ligands engage cell-surface …

The study of gastric epithelial homeostasis and cancer has been hampered by the lack of
stem cell markers and in vitro culture methods. The Wnt target gene Lgr5 marks stem cells in …